Open thread….blog while we get ready for GretaLiveWire (9:45pm) and ON THE RECORD (10pm eastern!)
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Wednesday, May 14, 2008
GretaLiveWire (9:45pm) and ON THE RECORD (10pm eastern)!!
Don’t forget to watch GretaLiveWire tonight!! It is on your computer before ON THE RECORD (which is on your television!)
The legal panel is back tonight ON THE RECORD and so I will draft them to come in early and appear on GretaLiveWire (our 9:45pm INTERNET SHOW - yes, on your computer!!)
If you have a special question for them post it on the GretaLiveWire icon that will go up at 8:30pm eastern.
Also…tonight ON THE RECORD ….Secretary Rice as VP??? plus more…. the prosecutor who is charging the teen in that Arizona bus brawl (you remember the video…..) will be on ON THE RECORD…many of you disagree with me about how that obnoxious teen should have been handled and I bet the prosecutor disagrees with me, too….I want to hear what he has to say and maybe he will convince me I am wrong…..
Tomorrow? Howard K. Stern (another guest who wants to tell me I am wrong!)
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Tuesday, May 13, 2008
[ Rock y Pop ] : q grupo de estos ta chido o cool??
Elegis a tu favorito o en todo caso haced una lista de q orden te gustaria o q grupos faltarian? !! Poison http://www.youtube.com/watch?v=sMqjGywYOI8 Bon Jovi http://www.youtube.com/watch?v=nE11Zrrp24I Guns and Roses http://www.youtube.com/watch?v=VlzptZ9wieQ&feature=related Dire Straits http://www.youtube.com/watch?v=aNaKWXqXkhw Nirvana http://www.youtube.com/watch?v=wY3oEvaq71A de estos 5 grupos elegid entre los 3 primeros cual ha sido el mejor o el q te ha llamado mas la atencion, de ahi despues elegid tu favorito o haced un top 5 !! esperad sus opiniones please!! byeee y como dice alex lora "Y Q VIVA EL ROCK AND ROLLLLLLLLLL" !!!!!!!!!!!!!!!!!!!!! a verdad me falto aerosmith http://www.youtube.com/watch?v=t4u5om4xihU solo son los grupos cuyos cantantes eran reconocidos o por sus voces o sus peinados en aquella epoca sigan opinando !!!!!!!!!! por favor kiero saber cual es su favorito realmente !!!!!!jejeje y despues lesdigo cuales son mis favoritos pero por favor q de los 3 primeros digan cual es mejor y de ahi hacen el top5 !!!!!!!!!!!!!!!!!!!!!!!!!!!
[ Otros - Música y Ocio ] : hola alguien que sepa ingles me puede traducir esta cancion ???
porque las traducciones de internet estan mal traducidas Letra de la cancion "Ready, Set, Don't Go" de Billy Ray y Miley Cyrus She's gotta do what she's gotta do And I've gotta like it or not She's got dreams too big for this town And she needs to give 'em a shot Whatever they are Looks like she's all ready to leave Nothing left to pack There ain't no room for me in that car Even if she asked me to tag along God I gotta be strong [Chorus] She's at the startin' line of the rest of her life As ready as she's ever been Got the hunger and the stars in her eyes The prize is hers to win She's waitin' on my blessings before she hits that open road Baby get ready Get set Don't go She says things are fallen into place Feels like they're fallen apart I painted this big ol' smile on my face To hide my broken heart If only she knew This is where I don't say what I want so bad to say This is where I want to but I won't get in the way Of her and her drea
Distinct Olfactory Cross-Modal Effects on the Human Motor System
by Simone Rossi, Alberto De Capua, Patrizio Pasqualetti, Monica Ulivelli, Luciano Fadiga, Vincenzo Falzarano, Sabina Bartalini, Stefano Passero, Daniele Nuti, Paolo M. Rossini
BackgroundConverging evidence indicates that action observation and action-related sounds activate cross-modally the human motor system. Since olfaction, the most ancestral sense, may have behavioural consequences on human activities, we causally investigated by transcranial magnetic stimulation (TMS) whether food odour could additionally facilitate the human motor system during the observation of grasping objects with alimentary valence, and the degree of specificity of these effects.
Methodology/Principal FindingsIn a repeated-measure block design, carried out on 24 healthy individuals participating to three different experiments, we show that sniffing alimentary odorants immediately increases the motor potentials evoked in hand muscles by TMS of the motor cortex. This effect was odorant-specific and was absent when subjects were presented with odorants including a potentially noxious trigeminal component.
The smell-induced corticospinal facilitation of hand muscles during observation of grasping was an additive effect which superimposed to that induced by the mere observation of grasping actions for food or non-food objects. The odour-induced motor facilitation took place only in case of congruence between the sniffed odour and the observed grasped food, and specifically involved the muscle acting as prime mover for hand/fingers shaping in the observed action.
Conclusions/SignificanceComplex olfactory cross-modal effects on the human corticospinal system are physiologically demonstrable. They are odorant-specific and, depending on the experimental context, muscle- and action-specific as well. This finding implies potential new diagnostic and rehabilitative applications.
[ Otros - Relaciones Familiares ] : hacer un comic para alguien que me gusta es buena idea con una cancion qque me guste!!?
bueno, lo quiero hacer en vez de escribir una cancion que me gusta para una chava, hacer como un comic lo que dice la cancion en vez de poner letras!! a ver si entienden mi pregunta! International You Day" i'm sorry that it took so long to write this song but i gave up you see one million words can't describe how it feels to know your love where did i go wrong? i should have told you from the start that i'm closer then you think when we're apart nothing that i've tried is as simple as this line but without you my life is incomplete my days are absolutely gray and so I'll try let your heart know for sure that i have so much more to tell you every single day i swear i'm giving up my inside to the one that i adorded i know this world is big enough for you and i but i'll give you more i'm coming home today to wipe the tears right from your eyes i'm totally enamored by your life nothing that i've done has ever been for one but without you my life is incomplete my days are absolutely gray and so I'll try let your heart know for sure that i have so much more to tell you every single day my life is incomplete my rites are absolutely gone so wake me up before you leave today something i need to say cause they'll be nothing when you're gone
Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in
by Koichi Iijima, Hsueh-Cheng Chiang, Stephen A. Hearn, Inessa Hakker, Anthony Gatt, Christopher Shenton, Linda Granger, Amy Leung, Kanae Iijima-Ando, Yi Zhong
Aggregation of the amyloid-β-42 (Aβ42) peptide in the brain parenchyma is a pathological hallmark of Alzheimer's disease (AD), and the prevention of Aβ aggregation has been proposed as a therapeutic intervention in AD. However, recent reports indicate that Aβ can form several different prefibrillar and fibrillar aggregates and that each aggregate may confer different pathogenic effects, suggesting that manipulation of Aβ42 aggregation may not only quantitatively but also qualitatively modify brain pathology. Here, we compare the pathogenicity of human Aβ42 mutants with differing tendencies to aggregate. We examined the aggregation-prone, EOFAD-related Arctic mutation (Aβ42Arc) and an artificial mutation (Aβ42art) that is known to suppress aggregation and toxicity of Aβ42 in vitro. In the Drosophila brain, Aβ42Arc formed more oligomers and deposits than did wild type Aβ42, while Aβ42art formed fewer oligomers and deposits. The severity of locomotor dysfunction and premature death positively correlated with the aggregation tendencies of Aβ peptides. Surprisingly, however, Aβ42art caused earlier onset of memory defects than Aβ42. More remarkably, each Aβ induced qualitatively different pathologies. Aβ42Arc caused greater neuron loss than did Aβ42, while Aβ42art flies showed the strongest neurite degeneration. This pattern of degeneration coincides with the distribution of Thioflavin S-stained Aβ aggregates: Aβ42Arc formed large deposits in the cell body, Aβ42art accumulated preferentially in the neurites, while Aβ42 accumulated in both locations. Our results demonstrate that manipulation of the aggregation propensity of Aβ42 does not simply change the level of toxicity, but can also result in qualitative shifts in the pathology induced in vivo.
[ Idiomas ] : Nesesito la traduccion de esta rola porfa ayudenme?
Title: Take It Like A Man I get a little bit vicious Thats why you love me Because you can't resist it You do anything for me You want out but we're off the ground So pick out your parachute Cause I'm not gonna let you down I won't let you get away its not that easy anyway I don't want to know and I want you for the cause How does anybody get anything done? You depend on us You'll never get to heaven as the radical son Just keep it up you soldier You won't help I can't help I've got to make you understand You gotta take it like a man Do you need a dozen roses Would you like a box of chocolate? Is it really such a deep cut That I have to come and stitch it up Yeah I get a little crazy with the razor blades Go on and call your mama if you need a band-aid But everything worth it hurts a little bit You don't want to run away, and I wont let you anyway 'Cause were doing it for the cause How do you suppose I get anything done? You're making it so hard You'll never get to heaven as the radical son Keep it up soldier You won't help I cant help I've got to make you understand You gotta take it like a man I want you for the cause How does anybody get anything done? You depend on us You'll never get to heaven as the radical son Don't be running off Cause this is love What did you think it was? Ooh.The thing is love, love So don't go! You won't help I cant help I've got to make you understand You gotta take it like a man Take it like a man You gotta take it like a man
Generalization Mediates Sensitivity to Complex Odor Features in the Honeybee
by Geraldine A. Wright, Sonya M. Kottcamp, Mitchell G. A. Thomson
Animals use odors as signals for mate, kin, and food recognition, a strategy which appears ubiquitous and successful despite the high intrinsic variability of naturally-occurring odor quantities. Stimulus generalization, or the ability to decide that two objects, though readily distinguishable, are similar enough to afford the same consequence [1], could help animals adjust to variation in odor signals without losing sensitivity to key inter-stimulus differences. The present study was designed to investigate whether an animal's ability to generalize learned associations to novel odors can be influenced by the nature of the associated outcome. We use a classical conditioning paradigm for studying olfactory learning in honeybees [2] to show that honeybees conditioned on either a fixed- or variable-proportion binary odor mixture generalize learned responses to novel proportions of the same mixture even when inter-odor differences are substantial. We also show that the resulting olfactory generalization gradients depend critically on both the nature of the stimulus-reward paradigm and the intrinsic variability of the conditioned stimulus. The reward dependency we observe must be cognitive rather than perceptual in nature, and we argue that outcome-dependent generalization is necessary for maintaining sensitivity to inter-odor differences in complex olfactory scenes.
Natural Variation in as a Tool for Highlighting Differential Drought Responses
by Oumaya Bouchabke, Fengqi Chang, Matthieu Simon, Roger Voisin, Georges Pelletier, Mylène Durand-Tardif
To test whether natural variation in Arabidopsis could be used to dissect out the genetic basis of responses to drought stress, we characterised a number of accessions. Most of the accessions belong to a core collection that was shown to maximise the genetic diversity captured for a given number of individual accessions in Arabidopsis thaliana. We measured total leaf area (TLA), Electrolyte Leakage (EL), Relative Water Content (RWC), and Cut Rosette Water Loss (CRWL) in control and mild water deficit conditions. A Principal Component Analysis revealed which traits explain most of the variation and showed that some accessions behave differently compared to the others in drought conditions, these included Ita-0, Cvi-0 and Shahdara. This study relied on genetic variation found naturally within the species, in which populations are assumed to be adapted to their environment. Overall, Arabidopsis thaliana showed interesting phenotypic variations in response to mild water deficit that can be exploited to identify genes and alleles important for this complex trait.
Healthy Lifestyle Behaviour Decreasing Risks of Being Bullied, Violence and Injury
by Amelia R. Turagabeci, Keiko Nakamura, Takehito Takano
BackgroundBullying and violence are problems of aggression in schools among adolescents. Basic daily healthy practices including nutritious diet, hygiene and physical activity are common approaches in comprehensive health promotion programs in school settings, however thier relationship to these aggressive behaviours is vague. We attempted to show the advantages of these healthy lifestyle behaviours in 9 developing countries by examining the association with being frequently bullied, violence and injury.
Methodology/Principal FindingsA cross-sectional cross-national survey of 9 countries using the WHO Global School Based Student Health Survey dataset was used. Measurements included experiences of "being frequently bullied" in the preceding 30 days and violence/injury in the past 12 months. Association of risk behaviours (smoking, alcohol, sexual behaviour) and healthy lifestyle (nutrition, hygiene practices, physical activity) to being bullied, and violence/injury were assessed using multivariate logistic regression. Hygiene behaviour showed lower risks of being frequently bullied [male: RR = 0.7 (97.5CI: 0.5, 0.9); female: RR = 0.6 (0.5, 0.8)], and lower risk of experiences of violence/injury [RR = 0.7 (0.5, 0.9) for males], after controlling for risk behaviours, age, education, poverty, and country.
Conclusion/SignificanceHealthy lifestyle showed an association to decreased relative risk of being frequently bullied and violence/injury in developing countries. A comprehensive approach to risk and health promoting behaviours reducing bullying and violence is encouraged at school settings.
Poor Reporting of Scientific Leadership Information in Clinical Trial Registers
by Melanie Sekeres, Jennifer L. Gold, An-Wen Chan, Joel Lexchin, David Moher, Marleen L. P. Van Laethem, James Maskalyk, Lorraine Ferris, Nathan Taback, Paula A. Rochon
BackgroundIn September 2004, the International Committee of Medical Journal Editors (ICMJE) issued a Statement requiring that all clinical trials be registered at inception in a public register in order to be considered for publication. The World Health Organization (WHO) and ICMJE have identified 20 items that should be provided before a trial is considered registered, including contact information. Identifying those scientifically responsible for trial conduct increases accountability. The objective is to examine the proportion of registered clinical trials providing valid scientific leadership information.
Methodology/Principal FindingsWe reviewed clinical trial entries listing Canadian investigators in the two largest international and public trial registers, the International Standard Randomized Controlled Trial Number (ISRCTN) register, and ClinicalTrials.gov. The main outcome measures were the proportion of clinical trials reporting valid contact information for the trials' Principal Investigator (PI)/Co-ordinating Investigator/Study Chair/Site PI, and trial e-mail contact address, stratified by funding source, recruiting status, and register. A total of 1388 entries (142 from ISRCTN and 1246 from ClinicalTrials.gov) comprised our sample. We found non-compliance with mandatory registration requirements regarding scientific leadership and trial contact information. Non-industry and partial industry funded trials were significantly more likely to identify the individual responsible for scientific leadership (OR = 259, 95% CI: 95–701) and to provide a contact e-mail address (OR = 9.6, 95% CI: 6.6–14) than were solely industry funded trials.
Conclusions/SignificanceDespite the requirements set by WHO and ICMJE, data on scientific leadership and contact e-mail addresses are frequently omitted from clinical trials registered in the two leading public clinical trial registers. To promote accountability and transparency in clinical trials research, public clinical trials registers should ensure adequate monitoring of trial registration to ensure completion of mandatory contact information fields identifying scientific leadership
Gene Expression Profiling of a Mouse Model of Pancreatic Islet Dysmorphogenesis
by Laura Wilding Crawford, Elizabeth Tweedie Ables, Young Ah Oh, Braden Boone, Shawn Levy, Maureen Gannon
BackgroundIn the past decade, several transcription factors critical for pancreas organogenesis have been identified. Despite this success, many of the factors necessary for proper islet morphogenesis and function remain uncharacterized. Previous studies have shown that transgenic over-expression of the transcription factor Hnf6 specifically in the pancreatic endocrine cell lineage resulted in disruptions in islet morphogenesis, including dysfunctional endocrine cell sorting, increased individual islet size, increased number of peripheral endocrine cell types, and failure of islets to migrate away from the ductal epithelium. The mechanisms whereby maintained Hnf6 causes defects in islet morphogenesis have yet to be elucidated.
Methodology/Principal FindingsWe exploited the dysmorphic islets in Hnf6 transgenic animals as a tool to identify factors important for islet morphogenesis. Genome-wide microarray analysis was used to identify differences in the gene expression profiles of late gestation and early postnatal total pancreas tissue from wild type and Hnf6 transgenic animals. Here we report the identification of genes with an altered expression in Hnf6 transgenic animals and highlight factors with potential importance in islet morphogenesis. Importantly, gene products involved in cell adhesion, cell migration, ECM remodeling and proliferation were found to be altered in Hnf6 transgenic pancreata, revealing specific candidates that can now be analyzed directly for their role in these processes during islet development.
Conclusions/SignificanceThis study provides a unique dataset that can act as a starting point for other investigators to explore the role of the identified genes in pancreatogenesis, islet morphogenesis and mature β cell function.
Promoter Demethylation Reveals the Committed Treg Population in Humans
by Peter C. J. Janson, Malin E. Winerdal, Per Marits, Magnus Thörn, Rolf Ohlsson, Ola Winqvist
BackgroundNaturally occurring thymus derived regulatory T cells (Tregs) are central in the maintenance of self-tolerance. The transcription factor FOXP3 is crucial for the suppressive activity of Tregs and is considered the most specific marker for this population. However, human non regulatory T cells upregulate FOXP3 transiently upon activation which calls for other means to identify the Treg population. Since epigenetic mechanisms are involved in the establishment of stable gene expression patterns during cell differentiation, we hypothesized that the methylation profile of the FOXP3 promoter would allow the distinction of truly committed Tregs.
Methodology/Principal FindingsHuman CD4+CD25hi Tregs displayed a demethylated FOXP3 promoter (1.4%±0.95% SEM methylated) in contrast to CD4+CD25lo T cells which were partially methylated (27.9%±7.1%). Furthermore, stimulated CD4+CD25lo T cells transiently expressed FOXP3 but remained partially methylated, suggesting promoter methylation as a mechanism for regulation of stable FOXP3 expression and Treg commitment. In addition, transient FOXP3 expressing cells exhibited suppressive abilities that correlate to the methylation status of the FOXP3 promoter. As an alternative to bisulphite sequencing, we present a restriction enzyme based screening method for the identification of committed Tregs and apply this method to evaluate the effect of various culturing conditions. We show that a partial demethylation occurs in long-term cultures after activation, whereas the addition of TGF-β and/or IL-10 does not induce any additional change in methylation level.
Conclusions/SignificanceThe unique FOXP3 promoter methylation profile in Tregs suggests that a demethylated pattern is a prerequisite for stable FOXP3 expression and suppressive phenotype. Presently, FOXP3 is used to identify Tregs in several human diseases and there are future implications for adoptive Treg transfer in immunotherapy. In these settings there is a need to distinguish true Tregs from transiently FOXP3+ activated T cells. The screening method we present allows this distinction and enables the identification of cells suitable for in vitro expansions and clinical use.
Monday, May 12, 2008
Muscleblind Is Involved in Alternative Splicing and Apoptosis
by Marta Vicente-Crespo, Maya Pascual, Juan M. Fernandez-Costa, Amparo Garcia-Lopez, Lidón Monferrer, M. Eugenia Miranda, Lei Zhou, Ruben D. Artero
BackgroundMuscleblind-like proteins (MBNL) have been involved in a developmental switch in the use of defined cassette exons. Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, to sequestration of MBNL proteins by CUG repeat RNA. Four protein isoforms (MblA-D) are coded by the unique Drosophila muscleblind gene.
Methodology/Principal FindingsWe used evolutionary, genetic and cell culture approaches to study muscleblind (mbl) function in flies. The evolutionary study showed that the MblC protein isoform was readily conserved from nematods to Drosophila, which suggests that it performs the most ancestral muscleblind functions. Overexpression of MblC in the fly eye precursors led to an externally rough eye morphology. This phenotype was used in a genetic screen to identify five dominant suppressors and 13 dominant enhancers including Drosophila CUG-BP1 homolog aret, exon junction complex components tsunagi and Aly, and pro-apoptotic genes Traf1 and reaper. We further investigated Muscleblind implication in apoptosis and splicing regulation. We found missplicing of troponin T in muscleblind mutant pupae and confirmed Muscleblind ability to regulate mouse fast skeletal muscle Troponin T (TnnT3) minigene splicing in human HEK cells. MblC overexpression in the wing imaginal disc activated apoptosis in a spatially restricted manner. Bioinformatics analysis identified a conserved FKRP motif, weakly resembling a sumoylation target site, in the MblC-specific sequence. Site-directed mutagenesis of the motif revealed no change in activity of mutant MblC on TnnT3 minigene splicing or aberrant binding to CUG repeat RNA, but altered the ability of the protein to form perinuclear aggregates and enhanced cell death-inducing activity of MblC overexpression.
Conclusions/SignificanceTaken together our genetic approach identify cellular processes influenced by Muscleblind function, whereas in vivo and cell culture experiments define Drosophila troponin T as a new Muscleblind target, reveal a potential involvement of MblC in programmed cell death and recognize the FKRP motif as a putative regulator of MblC function and/or subcellular location in the cell.
A Non-Human Primate Model for Gluten Sensitivity
by Michael T. Bethune, Juan T. Borda, Erin Ribka, Michael-Xun Liu, Kathrine Phillippi-Falkenstein, Ronald J. Jandacek, Gaby G. M. Doxiadis, Gary M. Gray, Chaitan Khosla, Karol Sestak
Background and AimsGluten sensitivity is widespread among humans. For example, in celiac disease patients, an inflammatory response to dietary gluten leads to enteropathy, malabsorption, circulating antibodies against gluten and transglutaminase 2, and clinical symptoms such as diarrhea. There is a growing need in fundamental and translational research for animal models that exhibit aspects of human gluten sensitivity.
MethodsUsing ELISA-based antibody assays, we screened a population of captive rhesus macaques with chronic diarrhea of non-infectious origin to estimate the incidence of gluten sensitivity. A selected animal with elevated anti-gliadin antibodies and a matched control were extensively studied through alternating periods of gluten-free diet and gluten challenge. Blinded clinical and histological evaluations were conducted to seek evidence for gluten sensitivity.
ResultsWhen fed with a gluten-containing diet, gluten-sensitive macaques showed signs and symptoms of celiac disease including chronic diarrhea, malabsorptive steatorrhea, intestinal lesions and anti-gliadin antibodies. A gluten-free diet reversed these clinical, histological and serological features, while reintroduction of dietary gluten caused rapid relapse.
ConclusionsGluten-sensitive rhesus macaques may be an attractive resource for investigating both the pathogenesis and the treatment of celiac disease.
The Effect of Inappropriate Calibration: Three Case Studies in Molecular Ecology
by Simon Y. W. Ho, Urmas Saarma, Ross Barnett, James Haile, Beth Shapiro
Time-scales estimated from sequence data play an important role in molecular ecology. They can be used to draw correlations between evolutionary and palaeoclimatic events, to measure the tempo of speciation, and to study the demographic history of an endangered species. In all of these studies, it is paramount to have accurate estimates of time-scales and substitution rates. Molecular ecological studies typically focus on intraspecific data that have evolved on genealogical scales, but often these studies inappropriately employ deep fossil calibrations or canonical substitution rates (e.g., 1% per million years for birds and mammals) for calibrating estimates of divergence times. These approaches can yield misleading estimates of molecular time-scales, with significant impacts on subsequent evolutionary and ecological inferences. We illustrate this calibration problem using three case studies: avian speciation in the late Pleistocene, the demographic history of bowhead whales, and the Pleistocene biogeography of brown bears. For each data set, we compare the date estimates that are obtained using internal and external calibration points. In all three cases, the conclusions are significantly altered by the application of revised, internally-calibrated substitution rates. Collectively, the results emphasise the importance of judicious selection of calibrations for analyses of recent evolutionary events.
Sunday, May 11, 2008
MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology
by Jyothi K. Mallajosyula, Deepinder Kaur, Shankar J. Chinta, Subramanian Rajagopalan, Anand Rane, David G. Nicholls, Donato A. Di Monte, Heather Macarthur, Julie K. Andersen
Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing antiparkinsonian therapy, is currently used clinically in concert with the dopamine precursor L-DOPA. Clinical studies suggesting that deprenyl treatment alone is not protective against PD associated mortality were targeted to symptomatic patients. However, dopamine loss is at least 60% by the time PD is symptomatically detectable, therefore lack of effect of MAO-B inhibition in these patients does not negate a role for MAO-B in pre-symptomatic dopaminergic loss. In order to directly evaluate the role of age-related elevations in astroglial MAO-B in the early initiation or progression of PD, we created genetically engineered transgenic mice in which MAO-B levels could be specifically induced within astroglia in adult animals. Elevated astrocytic MAO-B mimicking age related increase resulted in specific, selective and progressive loss of dopaminergic neurons in the substantia nigra (SN), the same subset of neurons primarily impacted in the human condition. This was accompanied by other PD-related alterations including selective decreases in mitochondrial complex I activity and increased mitochondrial oxidative stress. Along with a global astrogliosis, we observed local microglial activation within the SN. These pathologies correlated with decreased locomotor activity. Importantly, these events occurred even in the absence of the PD-inducing neurotoxin MPTP. Our data demonstrates that elevation of murine astrocytic MAO-B by itself can induce several phenotypes of PD, signifying that MAO-B could be directly involved in multiple aspects of disease neuropathology. Mechanistically this may involve increases in membrane permeant H2O2 which can oxidize dopamine within dopaminergic neurons to dopaminochrome which, via interaction with mitochondrial complex I, can result in increased mitochondrial superoxide. Our inducible astrocytic MAO-B transgenic provides a novel model for exploring pathways involved in initiation and progression of several key features associated with PD pathology and for therapeutic drug testing.
Ybp2 Associates with the Central Kinetochore of and Mediates Proper Mitotic Progression
by Kentaro Ohkuni, Rashid Abdulle, Amy Hin Yan Tong, Charles Boone, Katsumi Kitagawa
The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous mutations in one of several kinetochore and cohesion genes and a spindle checkpoint gene cause a synthetic-lethal or synthetic-sick phenotype. A synthetic genetic array (SGA) analysis using a mad2Δ query mutant strain of yeast identified YBP2, a gene whose product shares sequence similarity with the product of YBP1, which is required for H2O2-induced oxidation of the transcription factor Yap1. ybp2Δ was sensitive to benomyl and accumulated at the mitotic stage of the cell cycle. Ybp2 physically associates with proteins of the COMA complex (Ctf19, Okp1, Mcm21, and Ame1) and 3 components of the Ndc80 complex (Ndc80, Nuf2, and Spc25 but not Spc24) in the central kinetochore and with Cse4 (the centromeric histone and CENP-A homolog). Chromatin-immunoprecipitation analyses revealed that Ybp2 associates specifically with CEN DNA. Furthermore, ybp2Δ showed synthetic-sick interactions with mutants of the genes that encode the COMA complex components. Ybp2 seems to be part of a macromolecular kinetochore complex and appears to contribute to the proper associations among the central kinetochore subcomplexes and the kinetochore-specific nucleosome.
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Heads Up! NEW SimplyMobile for Moms survey for $20 amazon!!!! First 300 Only!
I got this in my email: ---Quote--- Thanks again for checking out SimplyMobile for Moms. We hope that you have had a chance to download the application and test it out, and we can't wait to hear...
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This is a content summary only. Please visit Slickdeals.net for the full details.
Friday, May 9, 2008
Head'sup - if you did the Doubletree Free choc chip cookie tin offer - you might get a mailer for a free $10 iTunes card - please read
I nearly tossed this when i got it - I was going thru mail from my offrice address and I noticed a small fold-out mailer from Renaissance New York Hotel addressed to me using a title I don't use...
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This is a content summary only. Please visit Slickdeals.net for the full details.
Altared Book Review
Altared Book Review by Nancy Eaton
The editor of this book, Colleen Curan, was engaged for three years before she was married. She was a little overcome by everything involved in planning a wedding. She was interested in finding out how women view weddings today. This book is a result of her findings.
This book includes 27 essays written by writers on all aspects involved in planning a wedding. The sections covered by the essays are, taking the vow, the dress, plans and preparations, etiquette and registry, weddings and the single girl, family and budget, getting hitched and for better or for worse.
This book is an entertaining read for anyone whether they are married or still single. It shows the reader all the stress and emotions that a bride-to-be goes through as she is planning her wedding. The reader will find the essays very funny at times and I'm sure they will bring back a few memories for some of the women who are now married and have gone through all the wedding planning stress. There are also a few more serious type essays such as the one written by Jennifer Armstrong that tells how she called off her wedding. This is a good read and one that I highly recommend.
Nancy Eaton Owner of:
Bestsellersworld.com
Mysteries Galore
Both websites have hundreds of book reviews.
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The editor of this book, Colleen Curan, was engaged for three years before she was married. She was a little overcome by everything involved in planning a wedding. She was interested in finding out how women view weddings today. This book is a result of her findings.
This book includes 27 essays written by writers on all aspects involved in planning a wedding. The sections covered by the essays are, taking the vow, the dress, plans and preparations, etiquette and registry, weddings and the single girl, family and budget, getting hitched and for better or for worse.
This book is an entertaining read for anyone whether they are married or still single. It shows the reader all the stress and emotions that a bride-to-be goes through as she is planning her wedding. The reader will find the essays very funny at times and I'm sure they will bring back a few memories for some of the women who are now married and have gone through all the wedding planning stress. There are also a few more serious type essays such as the one written by Jennifer Armstrong that tells how she called off her wedding. This is a good read and one that I highly recommend.
Nancy Eaton Owner of:
Bestsellersworld.com
Mysteries Galore
Both websites have hundreds of book reviews.
Article Directory: Article Dashboard
Who Do They Think They Are Kidding?
Who Do They Think They Are Kidding? by Thomas G. Holmshaw
E-mail marketing; let's just think about that for a moment! Put the credit card away, take a few minutes to collect your thoughts, and seriously consider the question posed in the title of this article. Then read on and take everything in.
OK so I want to get into internet marketing!
I've done all my homework, read all the articles, bought the E-books, joined the membership sites, oh! and not to forget all the lists that I have added my name and E-mail address to, as a trade for some valuable piece of secret information that will bring the answer to all my online marketing problems and send container loads of cash direct to my bank account 'AS I SLEEP' or 'WHILE I SPEND MY TIME WITH MY FAMILY ON SOME EXOTIC BEACH'..... PLEASE!!!! give me a break!
Sorry to shout but each time I open my E-mail account to see which self appointed 'GURU' has mailed me today, or which health product company has slipped through the spam filter with the name that is an anagram of some dubious part of the male anatomy, with the offer of giving me the sexual appetite of a rampant bull! I am faced with the same B.S.
There's a lot of great sounding products on the Internet, but you can't help but wonder, "Can I trust them to deliver what was promised in the sales letter? Will I get ripped-off, or is this really a good deal?"...
All I'm saying is that these internet marketing people at the top, have an awful lot of pulling power! and unfortunately, a large amount of the internet marketing community are desperate to make money, and therefore fall into the 'sheep mentality', allowing themselves to be shepherded through the internet marketing fields of the internet, and eventually to the market of monetization or even salesmanship slaughter!
The internet marketing 'Gurus' of today have pop star status and tremendous powers to influence their followers.
To return to the self appointed 'GURUS'; who do they think they are kidding?
Here are a few typical examples of the cliche`d, lame sales pitches I receive every day:
I managed to twist his arm to get him to reduce the price for my list....
Get over there fast before he comes to his senses and raises the price....
My good friend Fred Guru said I could offer you this bargain before he mails it to his list......
I wanted to give you the heads up on this because you are one of my favorite mugs......
I mean PLEASE! do they have to insult our intelligence? It would be nice to be given just a little credit for the brains that we have, in return for the loyalty of staying on their list.
The subject lines in the E-mails are also a little lacking in respect and leave a lot to be desired. So I have started verbally answering the questions they ask, or the statement they make, and either reading or deleting in accordance, here are a few examples:
First name, don't open this unless you want to become a millionaire!
My response, 'OK I won't' CLICK in the bin!
First name, just in case you didn't get my mail yesterday.....
My response, 'As a matter of fact I did get it, and it also ended up where this one is headed' CLICK in the bin!
First name, you have to open this NOW!!!
My response, 'NO I DON'T!' CLICK in the bin!
Now please don't get me wrong, I'm all for earning a living from the internet, and I give my name and Email, of my own free will because I believe that I can learn a lot from the genuine 'GURU'S' out there, but to get back to, and to really think about tha question I posed at the start of this article, who are they actually kidding? and what's more who can we really trust?
Please feel free to use this article, on the understanding that the article and this resource box are unchanged and included in their entirety: To view more articles by the author Thomas G. Holmshaw and receive your answers about who you can trust on the subject of internet E-mail marketing, please visit the following link: www.you-reviewit.com
Article Directory: Article Dashboard
E-mail marketing; let's just think about that for a moment! Put the credit card away, take a few minutes to collect your thoughts, and seriously consider the question posed in the title of this article. Then read on and take everything in.
OK so I want to get into internet marketing!
I've done all my homework, read all the articles, bought the E-books, joined the membership sites, oh! and not to forget all the lists that I have added my name and E-mail address to, as a trade for some valuable piece of secret information that will bring the answer to all my online marketing problems and send container loads of cash direct to my bank account 'AS I SLEEP' or 'WHILE I SPEND MY TIME WITH MY FAMILY ON SOME EXOTIC BEACH'..... PLEASE!!!! give me a break!
Sorry to shout but each time I open my E-mail account to see which self appointed 'GURU' has mailed me today, or which health product company has slipped through the spam filter with the name that is an anagram of some dubious part of the male anatomy, with the offer of giving me the sexual appetite of a rampant bull! I am faced with the same B.S.
There's a lot of great sounding products on the Internet, but you can't help but wonder, "Can I trust them to deliver what was promised in the sales letter? Will I get ripped-off, or is this really a good deal?"...
All I'm saying is that these internet marketing people at the top, have an awful lot of pulling power! and unfortunately, a large amount of the internet marketing community are desperate to make money, and therefore fall into the 'sheep mentality', allowing themselves to be shepherded through the internet marketing fields of the internet, and eventually to the market of monetization or even salesmanship slaughter!
The internet marketing 'Gurus' of today have pop star status and tremendous powers to influence their followers.
To return to the self appointed 'GURUS'; who do they think they are kidding?
Here are a few typical examples of the cliche`d, lame sales pitches I receive every day:
I managed to twist his arm to get him to reduce the price for my list....
Get over there fast before he comes to his senses and raises the price....
My good friend Fred Guru said I could offer you this bargain before he mails it to his list......
I wanted to give you the heads up on this because you are one of my favorite mugs......
I mean PLEASE! do they have to insult our intelligence? It would be nice to be given just a little credit for the brains that we have, in return for the loyalty of staying on their list.
The subject lines in the E-mails are also a little lacking in respect and leave a lot to be desired. So I have started verbally answering the questions they ask, or the statement they make, and either reading or deleting in accordance, here are a few examples:
First name, don't open this unless you want to become a millionaire!
My response, 'OK I won't' CLICK in the bin!
First name, just in case you didn't get my mail yesterday.....
My response, 'As a matter of fact I did get it, and it also ended up where this one is headed' CLICK in the bin!
First name, you have to open this NOW!!!
My response, 'NO I DON'T!' CLICK in the bin!
Now please don't get me wrong, I'm all for earning a living from the internet, and I give my name and Email, of my own free will because I believe that I can learn a lot from the genuine 'GURU'S' out there, but to get back to, and to really think about tha question I posed at the start of this article, who are they actually kidding? and what's more who can we really trust?
Please feel free to use this article, on the understanding that the article and this resource box are unchanged and included in their entirety: To view more articles by the author Thomas G. Holmshaw and receive your answers about who you can trust on the subject of internet E-mail marketing, please visit the following link: www.you-reviewit.com
Article Directory: Article Dashboard
How Top Management Uses Blogs To Increase Business
How Top Management Uses Blogs To Increase Business by Danny Wirken -
Top management executives at corporate giants like Sun Microsystems, Boeing Commercial Airplanes, General Motors and Hewlett-Packard have ventured into the blogging arena. What is prompting these busy executives to take time out form their hectic schedules to join in the conversations in the blogosphere? Simple, it is the desire to promote a new atmosphere of openness with employees, shareholders, customers, prospects and the general public in the process not only increasing business but, more so, giving a human voice to the company.
Bosses – Why Blog?
"What began as an experiment has become an important means of communication for GM. It has given me, personally, an opportunity to get much closer with you, the public." These are the words of General Motors vice chairman Bob Lutz. The blogosphere, the press, and most of GM's constituents are tuned into his blog which gets more than 5,000 visits and 13,000 page views a day.
In its simplest terms, a blog can be an online and very public journal. It is an effective medium used by top management to communicate directly to its market segment, business associates, stockholders and employees. Blogs serve as channels for management to explain to these people that the directions and actions and views that management is taking are in the best interests of all parties concerned. Through a blog, the CEO or any high level executive has the opportunity to converse with his target audience on a regular basis. The executive is in a unique position to set the agenda, steer the discussion and shape the views and opinions. In a way, top management executives would seem to be the logical persons to blog in behalf of the company. Nobody can represent a company and a product or service brand better than top executives especially the CEO. They are in a good position to comment on certain issues.
Blogging provides management with a fast and cost-effective means of conducting two-way communications with the company's audience. Management and customers, industry peers or the public all have the opportunity to respond either in the comment box or their very own blogs. Management wants to find out how the public views the company so it can improve its products or services. Listening and engaging the blogging community can turn out to be a highly effective way of discovering what your targeted audience thinks about your company. Top management can use feedbacks, good and bad, to their advantage. These feedbacks are used to improve products or services and systems. The immediate and open communication achieved thru blogging can enable a company to gain a high position in its industry. Corporate executive blogs also provide a fast and direct method of managing research on customer experiences, company perception, commentaries on policies and agenda.
Unfavorable comments are not filtered out. Management evaluates these inputs and responds accordingly. GM vice chairman Bob Lutz emphasized it is extremely important to run the bad with the good comments or else credibility will suffer. In the blogosphere, credibility counts the most. Once it is gone, the blog is useless. Filtering out the unsavory remarks takes away the essence of a real conversation. It completely eliminates the likelihood of any wrong perception about your product or service being corrected.
As a whole, top management executives use blogs to help generate sales thereby increasing business. Blogs help them develop a human voice that customers, prospects, shareholders, industry peers, employees and the general public can relate. Giving a human voice to the company is significant as people basically do business out of relationships as they do out of prices and benefits. Blogging promotes a two-way communication about what is important to companies and communities – dialogue that more often than not builds a working relationship.
Effective Executive Blogs
It takes a combination of passion, personality, expertise in one's field, wit and wisdom, writing proficiency to make an executive blog worth reading. An executive blog is not just a summary of company press releases. For a blog to be efficient, avoid having posts that read like a press release. Blogging is more informal and thus easier to bring readers into the conversation. Executive bloggers are advised to get personal while taking into consideration that a certain level of propriety is necessary.
Blogs are perfect for executives in as much as the focal point is on a subject matter that are an expert. An effective blog allows the executive to deal with business concerns and expound on major industry or company issues. For an executive blog to be successful, it should at all times reflect the conviction and voice of the executive, not the PR or legal department. This can be quite difficult as an executive blogger has added responsibilities to watch what he says, keeping in mind securities, disclosure rules. The best executive blog is one written by the executive himself. It is hard to be transparent when another blogger is posting opinions on industry or company trends that he has nothing to do with.
An effective blog uses short but concise and periodic entries rather than long and boring white papers. In fact, some of the outstanding blogs are those that have only one or two sentences with links directing readers to related articles.
A good executive blogger just focuses on two or three vital points. It is then scanned and proofread by a blog-savvy staff member. He also should organize the content of his blog. Arranging the corporate and industry issues he plans to tackle over time is recommended to build cohesiveness. Categorizing entries with relevant keywords can result in higher search engine ranking. New entries should be posted regularly, at least two to three times a week. There is nothing worse than visiting a blog that has not been updated.
Some executives hire the services of public relation firms to draw up blog strategies and at times to help them maintain the technical side of blogging. Others have in-house communications staff to handle logistics for them. Some executives write entries on their BlackBerrys or e-mail them. More importantly, executives claim they write their own blog personally with the slightest or no editing from the public relations or communications department.
Finally, to earn credibility in the blogosphere, an executive blogger should also take comments, favorable or not with a grain of salt. It also means owning up to bad news about the company. As Seth Godin, marketing guru and best-selling author emphasizes, an executive blog works best when it is based on candor, urgency, timeliness, pithiness, controversy and utility,
With the deluge of readers visiting blogs, expect more top management executives blogging to increase business.
http://www.theinternetone.net
Article Directory: Article Dashboard
Top management executives at corporate giants like Sun Microsystems, Boeing Commercial Airplanes, General Motors and Hewlett-Packard have ventured into the blogging arena. What is prompting these busy executives to take time out form their hectic schedules to join in the conversations in the blogosphere? Simple, it is the desire to promote a new atmosphere of openness with employees, shareholders, customers, prospects and the general public in the process not only increasing business but, more so, giving a human voice to the company.
Bosses – Why Blog?
"What began as an experiment has become an important means of communication for GM. It has given me, personally, an opportunity to get much closer with you, the public." These are the words of General Motors vice chairman Bob Lutz. The blogosphere, the press, and most of GM's constituents are tuned into his blog which gets more than 5,000 visits and 13,000 page views a day.
In its simplest terms, a blog can be an online and very public journal. It is an effective medium used by top management to communicate directly to its market segment, business associates, stockholders and employees. Blogs serve as channels for management to explain to these people that the directions and actions and views that management is taking are in the best interests of all parties concerned. Through a blog, the CEO or any high level executive has the opportunity to converse with his target audience on a regular basis. The executive is in a unique position to set the agenda, steer the discussion and shape the views and opinions. In a way, top management executives would seem to be the logical persons to blog in behalf of the company. Nobody can represent a company and a product or service brand better than top executives especially the CEO. They are in a good position to comment on certain issues.
Blogging provides management with a fast and cost-effective means of conducting two-way communications with the company's audience. Management and customers, industry peers or the public all have the opportunity to respond either in the comment box or their very own blogs. Management wants to find out how the public views the company so it can improve its products or services. Listening and engaging the blogging community can turn out to be a highly effective way of discovering what your targeted audience thinks about your company. Top management can use feedbacks, good and bad, to their advantage. These feedbacks are used to improve products or services and systems. The immediate and open communication achieved thru blogging can enable a company to gain a high position in its industry. Corporate executive blogs also provide a fast and direct method of managing research on customer experiences, company perception, commentaries on policies and agenda.
Unfavorable comments are not filtered out. Management evaluates these inputs and responds accordingly. GM vice chairman Bob Lutz emphasized it is extremely important to run the bad with the good comments or else credibility will suffer. In the blogosphere, credibility counts the most. Once it is gone, the blog is useless. Filtering out the unsavory remarks takes away the essence of a real conversation. It completely eliminates the likelihood of any wrong perception about your product or service being corrected.
As a whole, top management executives use blogs to help generate sales thereby increasing business. Blogs help them develop a human voice that customers, prospects, shareholders, industry peers, employees and the general public can relate. Giving a human voice to the company is significant as people basically do business out of relationships as they do out of prices and benefits. Blogging promotes a two-way communication about what is important to companies and communities – dialogue that more often than not builds a working relationship.
Effective Executive Blogs
It takes a combination of passion, personality, expertise in one's field, wit and wisdom, writing proficiency to make an executive blog worth reading. An executive blog is not just a summary of company press releases. For a blog to be efficient, avoid having posts that read like a press release. Blogging is more informal and thus easier to bring readers into the conversation. Executive bloggers are advised to get personal while taking into consideration that a certain level of propriety is necessary.
Blogs are perfect for executives in as much as the focal point is on a subject matter that are an expert. An effective blog allows the executive to deal with business concerns and expound on major industry or company issues. For an executive blog to be successful, it should at all times reflect the conviction and voice of the executive, not the PR or legal department. This can be quite difficult as an executive blogger has added responsibilities to watch what he says, keeping in mind securities, disclosure rules. The best executive blog is one written by the executive himself. It is hard to be transparent when another blogger is posting opinions on industry or company trends that he has nothing to do with.
An effective blog uses short but concise and periodic entries rather than long and boring white papers. In fact, some of the outstanding blogs are those that have only one or two sentences with links directing readers to related articles.
A good executive blogger just focuses on two or three vital points. It is then scanned and proofread by a blog-savvy staff member. He also should organize the content of his blog. Arranging the corporate and industry issues he plans to tackle over time is recommended to build cohesiveness. Categorizing entries with relevant keywords can result in higher search engine ranking. New entries should be posted regularly, at least two to three times a week. There is nothing worse than visiting a blog that has not been updated.
Some executives hire the services of public relation firms to draw up blog strategies and at times to help them maintain the technical side of blogging. Others have in-house communications staff to handle logistics for them. Some executives write entries on their BlackBerrys or e-mail them. More importantly, executives claim they write their own blog personally with the slightest or no editing from the public relations or communications department.
Finally, to earn credibility in the blogosphere, an executive blogger should also take comments, favorable or not with a grain of salt. It also means owning up to bad news about the company. As Seth Godin, marketing guru and best-selling author emphasizes, an executive blog works best when it is based on candor, urgency, timeliness, pithiness, controversy and utility,
With the deluge of readers visiting blogs, expect more top management executives blogging to increase business.
http://www.theinternetone.net
Article Directory: Article Dashboard
Songs About Cats or are they?
Songs About Cats (or are they?) by Larry Chamberlain
Perhaps the most famous Cat Song is The Siamese Cat Song recorded by Peggy Lee. The song is from the Walt Disney 1955 classic 'The Lady and The Tramp', an animated film about a classy Cocker Spaniel named Lady who falls for Tramp a scamp of a mongrel. The song however is about two arrogant cats, Si and Am, who have given Siamese cats a bad name ever since.
The Siamese Cat Song was penned by Lee along with Sonny Burke and over the years has also been recorded by Freddie and The Dreamers, Mitch Miller, Dave Stewart and Barbara Gaskin, Haylie Duff, and Bobby McFerrin. 'We are Siamese if you please, We are Siamese if you don't please.'
Both The Turtles and Petula Clark stepped into recording studios to make very different versions of The Cat in the Window, a song that compares a cat trying to get out of a window with the singer wanting to fly away. 'There's a cat in the window, and he's watching all the birds go passing by, he'd love to fly out the window, go where the wind goes, and so would I.'
Who can forget the Muppets recording of The Cat Came Back, a song about a kitty that just kept finding its way back no matter how far it was taken from home. 'But the cat came back, she wouldn't stay away, she was sitting on the porch the very next day.'
In 1950 folks were flooding into record stores and asking for I Tawt I Taw a Puddy Tat. Mel Blanc recorded the song, written by Alan Livingston, Billy May and Warren Foster, about the cartoon cat and canary duo Sylvester and Tweety. 'I tawt I taw a puddy tat a creeping up on me, I did I taw a puddy tat as plain as he could be.'
The Rooftop Singers followed up their 1963 number one hit Walk Right In, with Tom Cat a ditty about 'Ringtail Tom' who liked to go 'strutting round the town' 'And when he steps out all the other cats in the neighborhood they begin to shout.' Fast forward to 1981 and the Stray Cats record a musically different song but with a very similar theme, the rockabilly Stray Cat Strut. 'Stray cat strut, I'm a ladies' cat, a feline Casanova, hey man, that's where it's at, get a shoe thrown at me from a mean old man, get my dinner from a garbage can.'
Norma Tanega apparently owned a cat that she named 'Dog' and liked to take that cat for walks, hence her 1966 hit Walking My Cat Named Dog, which does seem to be about her real life experience of strolling around town with her pet feline.
Most songs though that include the word Cat in the tile, are not truly about cats at all. A great example is the fine song, Cats in the Cradle by Harry Chapin. No cats make an appearance in this song; instead the lyrics contain a very chilling message that every dad should pay heed too.
Bent Fabric, real name Bent Fabricius-Bjerre, had a hit in 1962 with Alley Cat, but this was an instrumental recording so it's not a song about cats. Instrumental too was Aaron Copeland's The Cat and the Mouse.
Cat People (Putting Out Fire) by David Bowie was recorded for the 1982 remake of the film Cat People. Great dark and menacing feel to the song but the words have no relationship to cats.
The cat in The Cat Crept In, recorded by Mud was actually a girl, as was the cat featured in The Rolling Stones' Stray Cat Blues, this one with exceedingly sharp claws.
They Call Her the Cat, by Elton John is about, well it's not about cats! Neither is Honky Cat, another Elton tune, that one is about a country boy moving to live life in the city.
Three Cool Cats, is a song that was first recorded by the Coasters in 1958 and covered by The Beatles in 1962 (but not released until 1995.) Of course this song is not about cats, but about three teenage boys and three teenage girls. The Beatles also recorded Little Willie John's Leave My Kitten Alone, no surprise to find that the song is not about a kitten.
U2 recorded a song titled An Cat Dubh, which apparently means The Black Cat in Gaelic, no cat in the song though, black or otherwise.
No cats are in Year of the Cat by Al Stewart, Cat Scratch Fever by Ted Nugent,
The Lovecats by The Cure or in Cool for Cats by Squeeze. Who can say what The Cat's In the Well by Bob Dylan is about?
There must be countless other songs that have the words Cat, or Cats, in the title but are not actually about our feline friends. No doubt there are more songs that are about cats than those listed on this page, but those songs sadly seem few and far between.
But wait . . . wasn't there a stage musical all about cats. Cats, the musical by
Andrew Lloyd Webber, was first shown in London, England in 1981. Based upon T. S. Eliot's Old Possum's Book of Practical Cats the show features song after song about . . . Old Gumbie, Grizabella, Mungojerrie And Rumpelteazer, Skimbleshanks, Old Deuteronomy, Gus, Macavity, and Mr. Mistoffelees. All of these characters are, of course, . . . Cats.
Please feel free to use this article on your cat or pet related web site or in your ezine. Please keep it intact including this resource box, (you may make minor formatting alterations,) and keep all links as hyperlinks. Thank you. Cat Art and all things Cat Great Pictures of Cats
Article Directory: Article Dashboard
Perhaps the most famous Cat Song is The Siamese Cat Song recorded by Peggy Lee. The song is from the Walt Disney 1955 classic 'The Lady and The Tramp', an animated film about a classy Cocker Spaniel named Lady who falls for Tramp a scamp of a mongrel. The song however is about two arrogant cats, Si and Am, who have given Siamese cats a bad name ever since.
The Siamese Cat Song was penned by Lee along with Sonny Burke and over the years has also been recorded by Freddie and The Dreamers, Mitch Miller, Dave Stewart and Barbara Gaskin, Haylie Duff, and Bobby McFerrin. 'We are Siamese if you please, We are Siamese if you don't please.'
Both The Turtles and Petula Clark stepped into recording studios to make very different versions of The Cat in the Window, a song that compares a cat trying to get out of a window with the singer wanting to fly away. 'There's a cat in the window, and he's watching all the birds go passing by, he'd love to fly out the window, go where the wind goes, and so would I.'
Who can forget the Muppets recording of The Cat Came Back, a song about a kitty that just kept finding its way back no matter how far it was taken from home. 'But the cat came back, she wouldn't stay away, she was sitting on the porch the very next day.'
In 1950 folks were flooding into record stores and asking for I Tawt I Taw a Puddy Tat. Mel Blanc recorded the song, written by Alan Livingston, Billy May and Warren Foster, about the cartoon cat and canary duo Sylvester and Tweety. 'I tawt I taw a puddy tat a creeping up on me, I did I taw a puddy tat as plain as he could be.'
The Rooftop Singers followed up their 1963 number one hit Walk Right In, with Tom Cat a ditty about 'Ringtail Tom' who liked to go 'strutting round the town' 'And when he steps out all the other cats in the neighborhood they begin to shout.' Fast forward to 1981 and the Stray Cats record a musically different song but with a very similar theme, the rockabilly Stray Cat Strut. 'Stray cat strut, I'm a ladies' cat, a feline Casanova, hey man, that's where it's at, get a shoe thrown at me from a mean old man, get my dinner from a garbage can.'
Norma Tanega apparently owned a cat that she named 'Dog' and liked to take that cat for walks, hence her 1966 hit Walking My Cat Named Dog, which does seem to be about her real life experience of strolling around town with her pet feline.
Most songs though that include the word Cat in the tile, are not truly about cats at all. A great example is the fine song, Cats in the Cradle by Harry Chapin. No cats make an appearance in this song; instead the lyrics contain a very chilling message that every dad should pay heed too.
Bent Fabric, real name Bent Fabricius-Bjerre, had a hit in 1962 with Alley Cat, but this was an instrumental recording so it's not a song about cats. Instrumental too was Aaron Copeland's The Cat and the Mouse.
Cat People (Putting Out Fire) by David Bowie was recorded for the 1982 remake of the film Cat People. Great dark and menacing feel to the song but the words have no relationship to cats.
The cat in The Cat Crept In, recorded by Mud was actually a girl, as was the cat featured in The Rolling Stones' Stray Cat Blues, this one with exceedingly sharp claws.
They Call Her the Cat, by Elton John is about, well it's not about cats! Neither is Honky Cat, another Elton tune, that one is about a country boy moving to live life in the city.
Three Cool Cats, is a song that was first recorded by the Coasters in 1958 and covered by The Beatles in 1962 (but not released until 1995.) Of course this song is not about cats, but about three teenage boys and three teenage girls. The Beatles also recorded Little Willie John's Leave My Kitten Alone, no surprise to find that the song is not about a kitten.
U2 recorded a song titled An Cat Dubh, which apparently means The Black Cat in Gaelic, no cat in the song though, black or otherwise.
No cats are in Year of the Cat by Al Stewart, Cat Scratch Fever by Ted Nugent,
The Lovecats by The Cure or in Cool for Cats by Squeeze. Who can say what The Cat's In the Well by Bob Dylan is about?
There must be countless other songs that have the words Cat, or Cats, in the title but are not actually about our feline friends. No doubt there are more songs that are about cats than those listed on this page, but those songs sadly seem few and far between.
But wait . . . wasn't there a stage musical all about cats. Cats, the musical by
Andrew Lloyd Webber, was first shown in London, England in 1981. Based upon T. S. Eliot's Old Possum's Book of Practical Cats the show features song after song about . . . Old Gumbie, Grizabella, Mungojerrie And Rumpelteazer, Skimbleshanks, Old Deuteronomy, Gus, Macavity, and Mr. Mistoffelees. All of these characters are, of course, . . . Cats.
Please feel free to use this article on your cat or pet related web site or in your ezine. Please keep it intact including this resource box, (you may make minor formatting alterations,) and keep all links as hyperlinks. Thank you. Cat Art and all things Cat Great Pictures of Cats
Article Directory: Article Dashboard
What is Software Piracy?
http://www.7paradise.net
http://www.kidandtoys.com
http://www.articleplanet.co.cc http://astore.amazon.com/kidandtoys-20
What is software piracy? There are several kinds of software piracy. The bottom line is when software is pirated, the developer does not receive compensation for their work.
Effects of Software Piracy
When software is pirated, consumers, software developers, and resellers are harmed. Software piracy increases the risk consumer's computers will be corrupted by defective software and infected with viruses. Those who provide defective and illegal software do not tend to provide sales and technical support. Pirated software usually has inadequate documentation, which prevents consumers from enjoying the full benefits of the software package. In addition, consumers are unable to take advantage of technical support and product upgrades, which are typically available to legitimate registered users of the software. Pirated software can cost consumers lost time and more money.
Developers lose revenue from pirated software, from current products as well as from future programs. When software is sold most developers invest a portion of the revenue into future development and better software packages. When software is pirated, software developers lose revenue from the sale of their products, which hinders development of new software and stifles the growth of the software company.
Kinds of Piracy
End User Piracy -
Using multiple copies of a single software package on several different systems or distributing registered or licensed copies of software to others. Another common form of end user piracy is when a cracked version of the software is used. Hacking into the software and disabling the copy protection, or illegally generating key codes that unlocks the trial version making the software a registered version creates a cracked version.
Reseller Piracy -
Reseller piracy occurs when an unscrupulous reseller distributes multiple copies of a single software package to different customers; this includes preloading systems with software without providing original manuals & diskettes. Reseller piracy also occurs when resellers knowingly sell counterfeit versions of software to unsuspecting customers.
Indications of reseller piracy are multiple users with the same serial number, lack of original documentation or an incomplete set, and non-matching documentation.
Trademark/Trade Name Infringement
Infringement occurs when an individual or dealer claims to be authorized either as a technician, support provider or reseller, or is improperly using a trademark or trade name.
BBS/Internet Piracy -
BBS/ Internet Piracy occurs when there is an electronic transfer of copyrighted software. If system operators and/or users upload or download copyrighted software and materials onto or from bulletin boards or the Internet for others to copy and use without the proper license. Often hackers will distribute or sell the hacked software or cracked keys. The developer does not receive any money for the software the hacker distributed. This is an infringement on the developer's copyright.
Another technique used by software pirates is to illegally obtain a registered copy of software. Pirates purchase the software once and use it on multiple computers. Purchasing software with a stolen credit card is another form of software piracy. Unfortunately there are many kinds of software piracy that has hampered the software industry.
These types of software piracy have hampered the software industry. For the software industry to prosper and further develop useful software for consumers please support and pay for software. This results in better software for all.
To Report Piracy :
Software Information Industry Association
About the author:
Sharon Housley manages marketing for NotePage, Inc. http://www.notepage.net a company specializing in alphanumeric paging, SMS and wireless messaging software solutions. Other sites by Sharon can be found at
www.softwaremarketingresource.com
Thursday, May 8, 2008
Buying a Home: How to Handle the Legal Documents
Buying a Home: How to Handle the Legal Documents by Hanu Nirukumurti
by Clare Stevens
Shopping for a home can be a little more complicated than finding the property and the money to pay for it. Between you and the night you sip champagne on the porch of your newly acquired house lie mounds of paperwork, with very small print, and jargon that you probably have neither the time nor inclination to wade through.
Why you need a conveyancer
That's what conveyancers are for. As solicitors who specialise in real estate properties, they can handle all the documents and make sure that you are fully protected by the law.
For example, if you're selling your home, your conveyancer will prepare the contracts and the property deeds. If you're buying one, he will coordinate with your mortgage lender and handle all the necessary searches to make sure that you're not being swindled out of your well-earned pounds. These include a local authority search (to check if your property is sitting on what will later be converted into a highway), a drainage search, a land registry search (so you know you're talking to the real owner of the property), and a land charges search (to assure the mortgage lender that you can afford the payments).
Some counties have an even longer list of required searches, making a conveyancer even more important. For example, Cheshire county residents need a brine search, to detect if the levels of minerals present in the ground can affect your house or your health. Most conveyancers will also evaluate your property for any damages or hazards that may need repair or correction, which he will then use to negotiate for a better sale price.
Your conveyancer will also be the one to deal with the solicitor of your house's seller (or buyer, whatever the case may be). He will prepare your offer sheet, schedule the necessary meetings and negotiations, and then prepare the final contracts. Once the sale has actually been made, your conveyancer will also take care of the deeds and make sure that the necessary documents are given to your mortgage lender.
Choosing a conveyancer
With the large amount of money involved in purchasing or selling a home, and the paperwork required by the institutions that will lend that money to you, the fees of a conveyancer are well worth the investment.
Some conveyancers charge a fixed rate, others set the amount according to a value of the property. However, fees should not be the sole determining factor behind your decision to hire someone as your legal representative. Choose someone that you're comfortable with, who offers excellent customer service, and will update you between the long stretches when documents are being processed. As a rule, legal firms that specialise in conveyancing are more likely to provide this kind of dedicated service. You are guaranteed that you are talking someone who knows the ins and outs of real estate, and will not have to worry that the person assigned to you isn't too busy in the courts to work on your documents.
It's also important to ask what is included in the fees, to uncover any hidden charges or at the very least clarify who will shoulder small costs of processing paperwork, such as documentary stamps.
Our property conveyancing team are always available when you need them most. For more information please visit http://www.rapidconveyancing.co.uk
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by Clare Stevens
Shopping for a home can be a little more complicated than finding the property and the money to pay for it. Between you and the night you sip champagne on the porch of your newly acquired house lie mounds of paperwork, with very small print, and jargon that you probably have neither the time nor inclination to wade through.
Why you need a conveyancer
That's what conveyancers are for. As solicitors who specialise in real estate properties, they can handle all the documents and make sure that you are fully protected by the law.
For example, if you're selling your home, your conveyancer will prepare the contracts and the property deeds. If you're buying one, he will coordinate with your mortgage lender and handle all the necessary searches to make sure that you're not being swindled out of your well-earned pounds. These include a local authority search (to check if your property is sitting on what will later be converted into a highway), a drainage search, a land registry search (so you know you're talking to the real owner of the property), and a land charges search (to assure the mortgage lender that you can afford the payments).
Some counties have an even longer list of required searches, making a conveyancer even more important. For example, Cheshire county residents need a brine search, to detect if the levels of minerals present in the ground can affect your house or your health. Most conveyancers will also evaluate your property for any damages or hazards that may need repair or correction, which he will then use to negotiate for a better sale price.
Your conveyancer will also be the one to deal with the solicitor of your house's seller (or buyer, whatever the case may be). He will prepare your offer sheet, schedule the necessary meetings and negotiations, and then prepare the final contracts. Once the sale has actually been made, your conveyancer will also take care of the deeds and make sure that the necessary documents are given to your mortgage lender.
Choosing a conveyancer
With the large amount of money involved in purchasing or selling a home, and the paperwork required by the institutions that will lend that money to you, the fees of a conveyancer are well worth the investment.
Some conveyancers charge a fixed rate, others set the amount according to a value of the property. However, fees should not be the sole determining factor behind your decision to hire someone as your legal representative. Choose someone that you're comfortable with, who offers excellent customer service, and will update you between the long stretches when documents are being processed. As a rule, legal firms that specialise in conveyancing are more likely to provide this kind of dedicated service. You are guaranteed that you are talking someone who knows the ins and outs of real estate, and will not have to worry that the person assigned to you isn't too busy in the courts to work on your documents.
It's also important to ask what is included in the fees, to uncover any hidden charges or at the very least clarify who will shoulder small costs of processing paperwork, such as documentary stamps.
Our property conveyancing team are always available when you need them most. For more information please visit http://www.rapidconveyancing.co.uk
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Pregnancy Tips for women
Pregnancy Tips for women by PaulB
Pregnancy Dos and Don'ts - The Do's
Follow these helpful hints to ensure your spouse a healthy pregnancy:
* Get all her essential vitamins and minerals every day. According to the U.S. Department of Health & Human Services, women need a lot more iron when pregnant. And sometimes it's hard to get enough by eating alone. Ask your doctor if your spouse should be taking a daily prenatal vitamin or multivitamin.
* Get 400 micrograms (or 0.4 mg) of folic acid daily in her diet. According to the U.S. Department of Health & Human Services, getting enough folic acid (or folate) reduces the chances of some birth defects. Some women eat lots of certain foods and others take multivitamins to get enough folic acid during pregnancy.
* Eat a healthy diet. Load her up on fruits, vegetables, and whole-grains (such as whole-wheat breads or crackers). Eat plenty of calcium-rich foods (such as non-fat or low-fat yogurt, milk, and broccoli) that your baby needs for strong bones and teeth. If you live in areas where fruits and vegetables aren't in season, frozen vegetables are a good option. Avoid giving her a lot of fatty foods (such as butter and fatty meats) to eat. Choose leaner foods when you can (such as skim milk, chicken and turkey without the skin, and fish).
* Let her gain a healthy, not excessive amount of weight. Research shows that women who gain more than the recommended amount during pregnancy have an elevated risk of obesity. On average, 25 to 30 pounds is a healthy weight gain over the 40 weeks of pregnancy. Check with your doctor to find out how much weight your spouse should gain during pregnancy
* Make sure she gets enough sleep (seven to nine hours every night). Aches, pains, anxiety and bathroom runs keep many pregnant women awake at night. To get some sleep, try getting your spouse to eat any large meals at least three hours before going to bed, get some easy exercise (like walking) and avoid long naps during the day. Make sure she sleeps on her left side and uses pillows between her legs and under her belly to help her get comfortable
* De-stress. If she can, your spouse should control the stress in her life. When it comes to work and family, she should figure out what she can really do. She should set limits with herself and others. Tell your spouse that she should not be afraid to say NO to requests for her time and energy
* Get Her Moving! Getting regular, low-impact exercise is good for your spouse and your baby. Talk to your doctor about what is safe. Get more guidelines on exercising while pregnant.
* Get a handle on health problems. Talk to your doctor about how your spouse's health problems can affect her and the baby. If she has diabetes, make sure she controls her blood sugar levels. If she has high blood pressure, monitor it closely. If she is overweight, talk to the doctor about whether she should lose weight.
* Ask your doctor before taking any medicines. According to the U.S. Department of Health & Human Services, prescription, over-the-counter, and herbal medicines all can harm your baby. Find out if your spouse should continue taking prescription medicines.
* See your doctor regularly. Prenatal care can help keep your spouse and the baby healthy, spot problems if they occur and prevent difficulties during delivery.
* Consider getting a flu shot. The flu can be dangerous for some moms-to-be. The Centers for Disease Control and Prevention (CDC) suggests vaccinations for all women who are at least 14 weeks pregnant during the flu season. Ask your doctor if your spouse should get a flu shot.
* Make sure she wears her seat-belt correctly. Seat belts used correctly protect your spouse and your unborn baby during a crash. The American Academy of Family Physicians recommends that pregnant women use seat belts that have a lap belt and a shoulder strap (3-point restraint). Seat belt straps should never go across her belly. The lap strap should go under the belly, across the hips. The shoulder strap should go off to the side of her belly and between her breasts. If she are not driving, the back seat is the safest place for her to sit.
* Ease the aches and pains. Don't just accept discomfort as a necessary part of pregnancy. Your spouse can easily be helped with problems related to hemorrhoids, heartburn, and leg cramps.
For more information about tips for pregnancy, please visit: http://www.greatdad.com
Author is an expert author for kids related advices. You can contact anytime for kids or parenting related issues.
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Pregnancy Dos and Don'ts - The Do's
Follow these helpful hints to ensure your spouse a healthy pregnancy:
* Get all her essential vitamins and minerals every day. According to the U.S. Department of Health & Human Services, women need a lot more iron when pregnant. And sometimes it's hard to get enough by eating alone. Ask your doctor if your spouse should be taking a daily prenatal vitamin or multivitamin.
* Get 400 micrograms (or 0.4 mg) of folic acid daily in her diet. According to the U.S. Department of Health & Human Services, getting enough folic acid (or folate) reduces the chances of some birth defects. Some women eat lots of certain foods and others take multivitamins to get enough folic acid during pregnancy.
* Eat a healthy diet. Load her up on fruits, vegetables, and whole-grains (such as whole-wheat breads or crackers). Eat plenty of calcium-rich foods (such as non-fat or low-fat yogurt, milk, and broccoli) that your baby needs for strong bones and teeth. If you live in areas where fruits and vegetables aren't in season, frozen vegetables are a good option. Avoid giving her a lot of fatty foods (such as butter and fatty meats) to eat. Choose leaner foods when you can (such as skim milk, chicken and turkey without the skin, and fish).
* Let her gain a healthy, not excessive amount of weight. Research shows that women who gain more than the recommended amount during pregnancy have an elevated risk of obesity. On average, 25 to 30 pounds is a healthy weight gain over the 40 weeks of pregnancy. Check with your doctor to find out how much weight your spouse should gain during pregnancy
* Make sure she gets enough sleep (seven to nine hours every night). Aches, pains, anxiety and bathroom runs keep many pregnant women awake at night. To get some sleep, try getting your spouse to eat any large meals at least three hours before going to bed, get some easy exercise (like walking) and avoid long naps during the day. Make sure she sleeps on her left side and uses pillows between her legs and under her belly to help her get comfortable
* De-stress. If she can, your spouse should control the stress in her life. When it comes to work and family, she should figure out what she can really do. She should set limits with herself and others. Tell your spouse that she should not be afraid to say NO to requests for her time and energy
* Get Her Moving! Getting regular, low-impact exercise is good for your spouse and your baby. Talk to your doctor about what is safe. Get more guidelines on exercising while pregnant.
* Get a handle on health problems. Talk to your doctor about how your spouse's health problems can affect her and the baby. If she has diabetes, make sure she controls her blood sugar levels. If she has high blood pressure, monitor it closely. If she is overweight, talk to the doctor about whether she should lose weight.
* Ask your doctor before taking any medicines. According to the U.S. Department of Health & Human Services, prescription, over-the-counter, and herbal medicines all can harm your baby. Find out if your spouse should continue taking prescription medicines.
* See your doctor regularly. Prenatal care can help keep your spouse and the baby healthy, spot problems if they occur and prevent difficulties during delivery.
* Consider getting a flu shot. The flu can be dangerous for some moms-to-be. The Centers for Disease Control and Prevention (CDC) suggests vaccinations for all women who are at least 14 weeks pregnant during the flu season. Ask your doctor if your spouse should get a flu shot.
* Make sure she wears her seat-belt correctly. Seat belts used correctly protect your spouse and your unborn baby during a crash. The American Academy of Family Physicians recommends that pregnant women use seat belts that have a lap belt and a shoulder strap (3-point restraint). Seat belt straps should never go across her belly. The lap strap should go under the belly, across the hips. The shoulder strap should go off to the side of her belly and between her breasts. If she are not driving, the back seat is the safest place for her to sit.
* Ease the aches and pains. Don't just accept discomfort as a necessary part of pregnancy. Your spouse can easily be helped with problems related to hemorrhoids, heartburn, and leg cramps.
For more information about tips for pregnancy, please visit: http://www.greatdad.com
Author is an expert author for kids related advices. You can contact anytime for kids or parenting related issues.
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How To Optimize Your Website For Google’s Top 10 R
Search engine optimization is the process of choosing targeted keyword phrases related to a website, and ensuring that the website places well when those keyword phrases are part of a Web search.
ON-PAGE OPTIMIZATION FACTORS:
The Major Factors Are:
Meta Tags, Header Tags, Text-body tag and Alt image tags:
1- META TAGS:
Meta Tags are code in your HTML that is invisible to the visitors of your web site but are read by some web spiders and search engines.
Meta tags used by a large percentage of the top search engines as one of the main guidelines on how they will index your site
The Main Meta Tags are:
• Title Tag
• Description Tag
• Keyword Tag
Targeting the right keywords:
Do keyword research- it is very important in building traffic
To do your keyword research visit this website http://inventory.overture.com/d/searchinventory/suggestion/
Select a short list of 3 to 4 keywords
Title tag:
The page title should include ONLY your main keywords. The least amount of words you can place in the title, the more weight Google will give to each of the keywords and the higher you will rank.
The title is the most important piece of information search engines use to index Web pages. Include the title of your page and 3-5 important keywords. Format your site title as follows:
Site title, keyword1, keyword2, keyword3
You may use your URL, or the name of your company as your site title.
• Make sure it specifically describes your product or service,
• Makes proper use of 3 or 4 keywords,
• Use between 10 and 80 characters long.
Tips:
• Taken out all of the 'ands'
• Replaced one of the 'ands' with a '|' character
• Always Combine Your Keywords In The Page Title
Description Tag:
The Meta description tag describes your site's content, giving search engines' spiders an accurate summary filled with multiple keywords.
• Use a descriptive paragraph or sentence that is relevant to your page.
• If possible, use a sentence or paragraph that is present in the content of your page
• Use up to 500 characters, including spaces.
Keyword Tag:
Use a list of keywords that are relevant to the content of your web page. Use your url as the first key word and separate the keywords with commas. Format the key words as follows:
www.sketch-plus.com, keyword1, keyword2, keyword3, …..
Add 5-10 Keywords
• For best results a tag sized between 50 and 250 characters.
• Note that keywords should be separated with commas.
Free Meta Tag Analyzer:
This Meta tag analysis tool will help you analyze your web pages and
check for search engine compatibility.
http://www.hypergurl.com/form.html
More Sites for SEO:
http://www.submitnet.net/
http://www.submitexpress.com/
2- HEADER TAGS:
Headers are used to break entries up into logical sections.
Add h1 header tags- (Place your most important keyword) it's best to place your h1 header tag on the top left hand or top/middle portion of your page.
When Google reads a webpage, it views the text from the top left hand side of the page to the bottom right hand side of the page.
Add h2 header tags- (Place your 2nd most important keyword) should be placed somewhere towards the top half of your webpage.
3- TEXT- BODY TAG:
The body element defines the documents' body. It contains all the contents of the document (like text, images, colors, graphics, etc.).
• When writing the content, try to evenly sprinkle your main keywords throughout the copy. Don't overdo it though.
• Try to mention each keyword in a natural way as you are writing
• Include at least one of the keywords per 1-2 paragraphs, depending on how large your page is.
• Make sure to mention your main keyword at the very top left and the very bottom right hand side of the webpage
• Bolding, italicizing and underlining...Once we've finished writing the copy, we should go through and bold, italicize, or underline some of the keywords only 1 time each, maximum.
• Any keyword must be used 4 times or more in your site's HTML body. This is highly recommended for best ranking results.
• Avoid Excessive Keywords- No word to be used more than 30 times throughout the page.
4- ALT IMAGE TAGS:
ALT tags are images' descriptions.
• Place your keyword 1 in the alt image tag of the very top image in your webpage.
• Place your other 2 keywords plus an extra word like 'picture' or 'image in the alt image tag of 2 more graphics throughout your webpage.
LOAD TIME ANALYSIS:
If your Web site does not load in 12 seconds or less with a 56k connection, statistics show that about 45% of visitors will leave the site.
• Optimized you site for 56k modem users- Load time 12 second or less.
• Try to keep your homepage under 50k and your other pages under 40k.
SEARCH ENGINE GUIDELINES:
Always remember this general rule when building your site: "Search engines do not like to be fooled". Do not try to manipulate your listings through sneaky methods. Provide useful, relevant content, and you will never have to worry about search engine guideline violations.
• Hidden Text - you never hide text.
• Excessive Keywords-Use keywords naturally in sentences and paragraphs.
• No word to be used more than 30 times throughout the page.
• Repeated Keywords- No keywords to be repeated multiple times in a row. We recommend using keywords naturally in sentences and paragraphs.
• Doorway Pages- Doorway pages are discouraged by most search engines.
• Harmful Redirects- Redirecting pages have a hard time being indexed by search engines.
• Frame Issues- It is recommended for sites that use frames to implement a descriptive NOFRAMES tag with relevant text content.
• Macromedia Flash Issues- Don't create all-Flash pages for any content you want to get indexed - instead, put that content in the HTML portion of the page.
Enjoy!
Article by Faraj Balousha, the founder of http://www.49adwinners.com and http://www.Sketch-Plus.com, he enjoys giving tips on how to design and develop your website. Do you want to learn about website design? Well, visit http://www.Creating-Website-Stores.com today!
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Dirty Celebrity Gossip | Celebrity Scandals | Celebrity Video | Celebrity Rumors |
Mp3 & Audio Search Engine
Mobile Phone Deals - Cost Effective Means Of Commu
Mobile Phone Deals - Cost Effective Means Of Communication
By Adam Caitlin
Mobile phones, the most efficient and wonderful communications device have become a necessity for our daily lives. In the present scenario, every class of people can afford a mobile phone. Thanks to the technology and the various cost-effective mobile phone deals that have given an economical and effective means of communication. Mobile phone deals play a major role and consumers can choose such deals based on their present requirements.
Mobile phone deals, being one of the economical means of communications have become very popular in the UK. It offers many gifts as well as monetary benefits that any consumers would wish while buying a new mobile handset or replace the existing one. Such contract deals come with special offers such as 12 months free line rental, 18 months free line rental, free texts, and other incentives. That's the main reason why consumers are getting more attracted with such mobile phone deals.
Consumers have the freedom to choose any mobile phone deals as per their needs and preferences. There are various kinds of mobile phone deals on all top mobile phone networks in the UK. Pick your choice of mobile handsets from leading brands such as Nokia, LG, Samsung, Sony Ericsson, etc., that are available on all leading UK mobile networks.
With many lucrative mobile phone deals on various mobile networks, consumers certainly get the privilege of choosing the best deal as per their needs. Special offers available on a particular network comes packed with cost effective tariff plans. Such plans are designed according to consumers needs and demands. You can choose any tariff plan based on the handset you select and the offers associated with them.
Before choosing any mobile phone deals, its important to know what special offers are available on a particular network. For most economical deals, you should know your priorities. Based on these few important things, you can choose the right choice – get connected with the people and the world, anytime-anywhere.
Adam Caitlin is expert author of Telecommunication industry. Mobile Phone Deals
Contract Mobile Phones
Article Source: http://EzineArticles.com/?expert=Adam_Caitlin
http://EzineArticles.com/?Mobile-Phone-Deals---Cost-Effective-Means-Of-Communication&id=630371
Credit Counseling Info Source
Credit Counseling Info Source by Uchenna Ani-Okoye
Unlike bankruptcy or debt settlement, you'll still be liable for paying the entire balance owed over a number of years, but as stated, if you can realistically commit to a long term payment arrangement, and you don't mind waiting a few extra years to become debt-free, consumer credit counseling may be right for you. As a result, many people are unsure if credit counseling can actually help them get out of debt. Typically, credit counseling involves working with the counselors to work out a financial strategy to manage the debts.
Credit counseling was created with the consumer in mind, some companies failed to recognize that. It helps to keep in mind that appropriate Federal and Senate committees have taken cognizance of the profitable nature of some of the non-profit credit counseling agencies. The biggest learning factor provided by a reputable consumer credit counseling agency will be knowledge they present you with in order to bring a more disciplined financial environment into your life resulting in less stress in terms of your current financial shape.
However, consumer credit counseling is not a free service and this, unfortunately, is a barrier in itself for those individuals too far in debt to afford the service. And, in case you find that you are not having a sound credit record, then, don't waste time to go for credit counseling because it helps immensely. Of course, counseling at the Consumer Credit Counseling Service is confidential and at no cost.
Contact Consumer Credit Counseling, As mentioned earlier, Consumer Credit Counseling is a non-profit group funded by creditors to help consumers negotiate repayment plans. Solid, reputable credit counseling agencies are an invaluable resource for debtors who have reached the end of their financial rope. Finally, it is important that you curb spending urges, since the benefits gained from the credit counseling will be lost if you have not learned to better manage your finances and avoid the situation that lead you to credit counseling in the first place.
It isn't going to do you any good to get out of debt if the credit counseling doesn't teach you how to manage your money so that you don't come knocking on debt's door again. Some families have found credit counseling to be one of the best solutions for avoiding bankruptcy. Credit Counseling Offers Third Party Advice, another option for debt consolidation is to get third party advice as to which program is best for your situation.
If you do find yourself in a predicament like this and you need professional help then you should really think of seeing a credit counselor or credit counseling service. You may want to check your particular states finance and banking department if you have questions regarding the status of the credit counseling organization you are speaking with. It is advisable to consult agencies that are accredited to either the Association of Independent Consumer Credit Counseling Agencies or the National Foundation for Credit Counseling.
If you'd like access to more information and resource links pertaining credit counseling, then check out my site at: Alberta Credit Counseling
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Unlike bankruptcy or debt settlement, you'll still be liable for paying the entire balance owed over a number of years, but as stated, if you can realistically commit to a long term payment arrangement, and you don't mind waiting a few extra years to become debt-free, consumer credit counseling may be right for you. As a result, many people are unsure if credit counseling can actually help them get out of debt. Typically, credit counseling involves working with the counselors to work out a financial strategy to manage the debts.
Credit counseling was created with the consumer in mind, some companies failed to recognize that. It helps to keep in mind that appropriate Federal and Senate committees have taken cognizance of the profitable nature of some of the non-profit credit counseling agencies. The biggest learning factor provided by a reputable consumer credit counseling agency will be knowledge they present you with in order to bring a more disciplined financial environment into your life resulting in less stress in terms of your current financial shape.
However, consumer credit counseling is not a free service and this, unfortunately, is a barrier in itself for those individuals too far in debt to afford the service. And, in case you find that you are not having a sound credit record, then, don't waste time to go for credit counseling because it helps immensely. Of course, counseling at the Consumer Credit Counseling Service is confidential and at no cost.
Contact Consumer Credit Counseling, As mentioned earlier, Consumer Credit Counseling is a non-profit group funded by creditors to help consumers negotiate repayment plans. Solid, reputable credit counseling agencies are an invaluable resource for debtors who have reached the end of their financial rope. Finally, it is important that you curb spending urges, since the benefits gained from the credit counseling will be lost if you have not learned to better manage your finances and avoid the situation that lead you to credit counseling in the first place.
It isn't going to do you any good to get out of debt if the credit counseling doesn't teach you how to manage your money so that you don't come knocking on debt's door again. Some families have found credit counseling to be one of the best solutions for avoiding bankruptcy. Credit Counseling Offers Third Party Advice, another option for debt consolidation is to get third party advice as to which program is best for your situation.
If you do find yourself in a predicament like this and you need professional help then you should really think of seeing a credit counselor or credit counseling service. You may want to check your particular states finance and banking department if you have questions regarding the status of the credit counseling organization you are speaking with. It is advisable to consult agencies that are accredited to either the Association of Independent Consumer Credit Counseling Agencies or the National Foundation for Credit Counseling.
If you'd like access to more information and resource links pertaining credit counseling, then check out my site at: Alberta Credit Counseling
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Computer Network Engineering Schools Offer Advance
Computer Network Engineering Schools Offer Advanced Degrees by Michael Bustamante
Computer Network Engineering Schools, colleges, and universities grant associate, bachelor, master, doctorate degrees, and post-graduate certificates in computer science. Computer schools teach the design, installation, configuration, and maintenance of computer system networks.
Computer network engineering students will develop a solid background in math and science, as well as skills in critical thinking, communication, logic, and problem solving. Courses in calculus and physics, in addition to computer programming and networking can be expected.
Bachelor degree students in computer network engineering university programs will be prepared for entry-level positions as network administrators and technical support specialists.
Master and doctorate degree programs emphasize specialized technical network engineering. Post-graduate certificate programs provide advanced topics of study, allowing students to develop expertise in specific areas.
Computer network engineering graduate degree programs are designed for engineers with bachelor degrees in electrical engineering, computer science, computer engineering, or a related discipline, and for engineers in the fields of design and development of network systems, components, products, and services.
Corporations and businesses use computer networks in daily functions, making the jobs of computer network engineers important for keeping these networks in good operating condition. Computer network engineers are prepared for a variety of duties involved in designing new computers, testing computers, and maintaining existing computer network systems.
Since keeping current with trends and developments in technology, graduates can anticipate continuing their education throughout their career in workshops and continuing education courses.
Computer network engineering careers will continue to grow with the growth and use of advancing technology. If you would like to learn more about Computer Network Engineering Education and Computer Network Engineering Schools please search our site for more in-depth information and resources.
DISCLAIMER: Above is a GENERAL OVERVIEW and may or may not reflect specific practices, courses and/or services associated with ANY ONE particular school(s) that is or is not advertised on our website.
Copyright 2007 - All rights reserved by Media Positive Communications, Inc.
Notice: Publishers are free to use this article on an ezine or website, provided the article is reprinted in its entirety, including copyright and disclaimer, and ALL links remain intact and active.
Find Computer Network Engineering Education and Computer Network Engineering Schools as well as Computer Schools, Colleges, Universities, Vocational and Trade Schools, and Online Schools at SchoolsGalore.com
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Computer Network Engineering Schools, colleges, and universities grant associate, bachelor, master, doctorate degrees, and post-graduate certificates in computer science. Computer schools teach the design, installation, configuration, and maintenance of computer system networks.
Computer network engineering students will develop a solid background in math and science, as well as skills in critical thinking, communication, logic, and problem solving. Courses in calculus and physics, in addition to computer programming and networking can be expected.
Bachelor degree students in computer network engineering university programs will be prepared for entry-level positions as network administrators and technical support specialists.
Master and doctorate degree programs emphasize specialized technical network engineering. Post-graduate certificate programs provide advanced topics of study, allowing students to develop expertise in specific areas.
Computer network engineering graduate degree programs are designed for engineers with bachelor degrees in electrical engineering, computer science, computer engineering, or a related discipline, and for engineers in the fields of design and development of network systems, components, products, and services.
Corporations and businesses use computer networks in daily functions, making the jobs of computer network engineers important for keeping these networks in good operating condition. Computer network engineers are prepared for a variety of duties involved in designing new computers, testing computers, and maintaining existing computer network systems.
Since keeping current with trends and developments in technology, graduates can anticipate continuing their education throughout their career in workshops and continuing education courses.
Computer network engineering careers will continue to grow with the growth and use of advancing technology. If you would like to learn more about Computer Network Engineering Education and Computer Network Engineering Schools please search our site for more in-depth information and resources.
DISCLAIMER: Above is a GENERAL OVERVIEW and may or may not reflect specific practices, courses and/or services associated with ANY ONE particular school(s) that is or is not advertised on our website.
Copyright 2007 - All rights reserved by Media Positive Communications, Inc.
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Find Computer Network Engineering Education and Computer Network Engineering Schools as well as Computer Schools, Colleges, Universities, Vocational and Trade Schools, and Online Schools at SchoolsGalore.com
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Email blasting from shared hosting
Email blasting from shared hosting by Roberto Bell
Sending large volume of emails from shared hosting is always a problem. Shared web hosting is not designed to allow 10,000 email sending at once. However, there is always a trick for this. See the pros and cons before we doing it.
First of all, email spamming is bad, and if you are sending unsolicited email or marketing letters to anyone in your mailing list. Consequences is that your hosting account will be suspended. Your domain name and IP address could be blacklisted as well. As it's a shared IP address, the hosting company will not want to take any risk, and shut you down whenever they smell that your launching email broadcasting to the whole world.
Now you had realized the consequences that you will get yourself into. Now, what if you are running a forum of 10,000 members, and you would like to email inform them about forums upgrade etc. What should you do, how to email to them at once if your shared hosting only allow 50 or 100 email sendings limit per hour??
First, check with your hosting provider, inform them you require to send out 10,000 emails from your website, and request them to give you the highest email sending limits. Let say now they set it to 500 emails per hour. And you will require to split your mailing list into 20 group and send them out each hour. That is a good beginning.
What if you are given only 100 or less email limit per hour. You will require to setup 100 groups. That is lots of work to do. Not to worry, some engineering work will solve this. First, insert all your email address into mysql database. Create a php file that pull out 100 emails and uses phpmail() to send them out one after another. By this you have the script that fetch 100 emails at a time. Then from cpanel use the crons job to schedule this script to run every hour, by that you will have 100 outgoing emails per hour.
Your email will keep sending out each hours, and make sure you not sending repeating to same recipient, they will going nuts receiving tons of email. After email sent, remove from mysql database. It's the safest thing to do.
Good luck to your email marketing effort, and this is the best solution you can have when using shared hosting.
Charles Gan
Recommended web hosting bluehost reviews at www.bluehostreview.org and powweb reviews
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Sending large volume of emails from shared hosting is always a problem. Shared web hosting is not designed to allow 10,000 email sending at once. However, there is always a trick for this. See the pros and cons before we doing it.
First of all, email spamming is bad, and if you are sending unsolicited email or marketing letters to anyone in your mailing list. Consequences is that your hosting account will be suspended. Your domain name and IP address could be blacklisted as well. As it's a shared IP address, the hosting company will not want to take any risk, and shut you down whenever they smell that your launching email broadcasting to the whole world.
Now you had realized the consequences that you will get yourself into. Now, what if you are running a forum of 10,000 members, and you would like to email inform them about forums upgrade etc. What should you do, how to email to them at once if your shared hosting only allow 50 or 100 email sendings limit per hour??
First, check with your hosting provider, inform them you require to send out 10,000 emails from your website, and request them to give you the highest email sending limits. Let say now they set it to 500 emails per hour. And you will require to split your mailing list into 20 group and send them out each hour. That is a good beginning.
What if you are given only 100 or less email limit per hour. You will require to setup 100 groups. That is lots of work to do. Not to worry, some engineering work will solve this. First, insert all your email address into mysql database. Create a php file that pull out 100 emails and uses phpmail() to send them out one after another. By this you have the script that fetch 100 emails at a time. Then from cpanel use the crons job to schedule this script to run every hour, by that you will have 100 outgoing emails per hour.
Your email will keep sending out each hours, and make sure you not sending repeating to same recipient, they will going nuts receiving tons of email. After email sent, remove from mysql database. It's the safest thing to do.
Good luck to your email marketing effort, and this is the best solution you can have when using shared hosting.
Charles Gan
Recommended web hosting bluehost reviews at www.bluehostreview.org and powweb reviews
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How Long Will Your Water Heater Last? Your Anode
How Long Will Your Water Heater Last? Your Anode Rods Will Tell Us. Part 2 by John Haynes
Copyright 2006 John Haynes
Anode Evaluation
If the anode rod has more sacrificial metal than exposed steel rod, then it is still in good shape. However, if the entire surface becomes covered in calcium carbonate and this calcium carbonate becomes hard, this will prevent the anode from protecting the tank any longer. This is known as passivation. If the anode has passivated, it will not look so by sight alone. To test for passivation, you must bend the anode rod by hand. At the bend, observe for small amounts of flaking. The anode should be replaced if more areas of the rod are exposed wire than sacrificial metal. It should also be replaced if the top or bottom of the rod has deteriorated, exposing six or more inches of exposed wire. An anode should also be replaced if the anode is less than half of the rod's 3/4 in. diameter size. If the anode has passivated, split through its length, or has become heavily pitted, it could also be time for replacement. When all the sacrificial metal has worn away, then the steel rod will begin to wear away. After the steel rod wears away, the only thing left will be the hex head or the hot water outlet nipple if it is a combination anode. At this point, the tank will begin to corrode. If the anode is found in the above stated conditions, damage to the tank may have already occurred.
Hidden Hex Head On Newer Models
Hex heads are threaded watertight plugs about 3/4 inches in diameter. They are attached to anode rods at the top of water heaters. Some are easily seen from the top of the water heater. Other times it will be under fiberglass or under a piece of plastic. To locate the hex head, drill a shallow 1/4 inch hole through the plastic top of the water heater. Do not drill deep into the tank itself. Use a long flat-head screwdriver to probe underneath the top of the water heater to find the hex head. On gas heaters, the hex head will be the same distance from the flue as the hot and cold lines are. On electrics, the anode will be off center so as not to drop on the heating elements. A few holes may need to be dug in order to locate the hex head. Once the hex head is found, it should be permanently exposed. Use a hole saw capable of cutting plastic or metal to carve a hole big enough to allow future access to the hex head. Use two people at this point to unscrew the hex head--one to steady the tank, the other to use a breaker bar and a socket that fits the head. Anywhere from 3/4 inch to 1-1/16 inch.
In the future, when buying a new water heater, purchase only those with already exposed hex heads.
Hidden Hex Head On Older Models
To find the hex head on older water heaters, simply unscrew the screws holding the top in place, mark the placement of the top and the water heater with a marker, then remove the top to find the hex head. Alas, many heaters found in today's buildings have foamed-in tops and can't be removed. Again, if the hex head is not exposed at the time of purchase, don't purchase that particular tank. Look for a tank with an already exposed hex head.
Anode Inspection
Anodes should be inspected at least every two years where softened water is used but at least every four years under normal water conditions. On occasion, the location of the anode is actually written on the water heater instructions.
Anode Installation
To remove the old rod, pull it as far out as possible, bend it, then pull it the rest of the way out. To install the new one, bend the rod directly in the middle, insert it half way, straighten it against the opening, and install it the rest of the way. Screw in the anode rod at this time. If you are unable to screw it into place because it is too bent, pull it partially out and use the opening to straighten it further. If there is not sufficent ceiling room to install the new anode rod, consider a link-anode. These anodes have many small links hooked together and look similar to links of sausages. You can also try zinc anodes because they bend far easier than magnesium ones. Another way to install an anode is to drain the water heater and tip it over enough to allow easy access for the anode.
Length
Anodes are typically 3 feet 8 inches. Anodes should be only a few inches shorter than the tank itself. Buy anodes that are a little too long instead of a little too short. This way you can cut the anode shorter if it is too tall.
Impressed-Current Rod
In relation to commercial water heaters, there are impressed current rods. These rods do not self-generate currents like sacrificial anodes. They derive power from an electrical power source. Many commercial heaters give the location of the impressed-current rod. They do not need to be replaced throughout their lifetime. They may need periodic cleaning. Simply wipe them off with a towel. If rust appears inside a water heater with an impressed-current rod, you should either call the manufacturer, call a plumber, or install sacrificial anodes.
Do you want to KNOW more than the water heater salesman? Check out http://www.waterheater-info.com which provides insight into warranties, insulation, and accessibility.
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Copyright 2006 John Haynes
Anode Evaluation
If the anode rod has more sacrificial metal than exposed steel rod, then it is still in good shape. However, if the entire surface becomes covered in calcium carbonate and this calcium carbonate becomes hard, this will prevent the anode from protecting the tank any longer. This is known as passivation. If the anode has passivated, it will not look so by sight alone. To test for passivation, you must bend the anode rod by hand. At the bend, observe for small amounts of flaking. The anode should be replaced if more areas of the rod are exposed wire than sacrificial metal. It should also be replaced if the top or bottom of the rod has deteriorated, exposing six or more inches of exposed wire. An anode should also be replaced if the anode is less than half of the rod's 3/4 in. diameter size. If the anode has passivated, split through its length, or has become heavily pitted, it could also be time for replacement. When all the sacrificial metal has worn away, then the steel rod will begin to wear away. After the steel rod wears away, the only thing left will be the hex head or the hot water outlet nipple if it is a combination anode. At this point, the tank will begin to corrode. If the anode is found in the above stated conditions, damage to the tank may have already occurred.
Hidden Hex Head On Newer Models
Hex heads are threaded watertight plugs about 3/4 inches in diameter. They are attached to anode rods at the top of water heaters. Some are easily seen from the top of the water heater. Other times it will be under fiberglass or under a piece of plastic. To locate the hex head, drill a shallow 1/4 inch hole through the plastic top of the water heater. Do not drill deep into the tank itself. Use a long flat-head screwdriver to probe underneath the top of the water heater to find the hex head. On gas heaters, the hex head will be the same distance from the flue as the hot and cold lines are. On electrics, the anode will be off center so as not to drop on the heating elements. A few holes may need to be dug in order to locate the hex head. Once the hex head is found, it should be permanently exposed. Use a hole saw capable of cutting plastic or metal to carve a hole big enough to allow future access to the hex head. Use two people at this point to unscrew the hex head--one to steady the tank, the other to use a breaker bar and a socket that fits the head. Anywhere from 3/4 inch to 1-1/16 inch.
In the future, when buying a new water heater, purchase only those with already exposed hex heads.
Hidden Hex Head On Older Models
To find the hex head on older water heaters, simply unscrew the screws holding the top in place, mark the placement of the top and the water heater with a marker, then remove the top to find the hex head. Alas, many heaters found in today's buildings have foamed-in tops and can't be removed. Again, if the hex head is not exposed at the time of purchase, don't purchase that particular tank. Look for a tank with an already exposed hex head.
Anode Inspection
Anodes should be inspected at least every two years where softened water is used but at least every four years under normal water conditions. On occasion, the location of the anode is actually written on the water heater instructions.
Anode Installation
To remove the old rod, pull it as far out as possible, bend it, then pull it the rest of the way out. To install the new one, bend the rod directly in the middle, insert it half way, straighten it against the opening, and install it the rest of the way. Screw in the anode rod at this time. If you are unable to screw it into place because it is too bent, pull it partially out and use the opening to straighten it further. If there is not sufficent ceiling room to install the new anode rod, consider a link-anode. These anodes have many small links hooked together and look similar to links of sausages. You can also try zinc anodes because they bend far easier than magnesium ones. Another way to install an anode is to drain the water heater and tip it over enough to allow easy access for the anode.
Length
Anodes are typically 3 feet 8 inches. Anodes should be only a few inches shorter than the tank itself. Buy anodes that are a little too long instead of a little too short. This way you can cut the anode shorter if it is too tall.
Impressed-Current Rod
In relation to commercial water heaters, there are impressed current rods. These rods do not self-generate currents like sacrificial anodes. They derive power from an electrical power source. Many commercial heaters give the location of the impressed-current rod. They do not need to be replaced throughout their lifetime. They may need periodic cleaning. Simply wipe them off with a towel. If rust appears inside a water heater with an impressed-current rod, you should either call the manufacturer, call a plumber, or install sacrificial anodes.
Do you want to KNOW more than the water heater salesman? Check out http://www.waterheater-info.com which provides insight into warranties, insulation, and accessibility.
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Extra-atrial expression of the gene for atrial natriuretic factor.
Proc Natl Acad Sci U S A, Vol. 83, No. 18. (September 1986), pp. 6697-6701.
Atrial natriuretic factor (ANF) is a group of peptides, originally isolated from the cardiac atria, that have a number of important effects on blood pressure, renal function, and salt balance. In the current study, expression of the ANF gene in certain extra-atrial tissues of the rat has been examined by radioimmunoassay of extracted ANF protein and by blot-hybridization, nuclease S1 analysis, and primer-extension analysis of the ANF mRNA. ANF peptides and mRNA were detected in cardiac ventricles, lung, and pituitary gland at levels generally less than or equal to 1% those of cardiac atria. The ANF transcripts in extra-atrial tissue appear to be very similar to those synthesized in the atria. They are polyadenylylated, are equivalent in overall length (950-1050 nucleotides), and have identical 5' termini. A secondary transcription start site mapping approximately 80 base pairs upstream from the primary start site is employed in atria and to a lesser extent in other tissues. The ANF transcript is present throughout the cardiac ventricles from apex to base and in the septum as well as the ventricular free walls. The transcript is more prevalent in the left ventricle and interventricular septum than in the right ventricle. Immunocytochemistry using various anti-rat ANF antibodies localized ANF immunoreactivity to the atrial myocytes; the ventricular myocytes, particularly along the endothelial surface of the ventricular chamber; perialveolar cells in the lung; and the gonadotropin-producing cells of the pituitary. The data indicate that the capacity for ANF gene expression extends beyond atrial tissue, albeit at much reduced levels, and may suggest alternative, perhaps paraendocrine, functions for the peptide in these tissues.
Atrial natriuretic factor (ANF) is a group of peptides, originally isolated from the cardiac atria, that have a number of important effects on blood pressure, renal function, and salt balance. In the current study, expression of the ANF gene in certain extra-atrial tissues of the rat has been examined by radioimmunoassay of extracted ANF protein and by blot-hybridization, nuclease S1 analysis, and primer-extension analysis of the ANF mRNA. ANF peptides and mRNA were detected in cardiac ventricles, lung, and pituitary gland at levels generally less than or equal to 1% those of cardiac atria. The ANF transcripts in extra-atrial tissue appear to be very similar to those synthesized in the atria. They are polyadenylylated, are equivalent in overall length (950-1050 nucleotides), and have identical 5' termini. A secondary transcription start site mapping approximately 80 base pairs upstream from the primary start site is employed in atria and to a lesser extent in other tissues. The ANF transcript is present throughout the cardiac ventricles from apex to base and in the septum as well as the ventricular free walls. The transcript is more prevalent in the left ventricle and interventricular septum than in the right ventricle. Immunocytochemistry using various anti-rat ANF antibodies localized ANF immunoreactivity to the atrial myocytes; the ventricular myocytes, particularly along the endothelial surface of the ventricular chamber; perialveolar cells in the lung; and the gonadotropin-producing cells of the pituitary. The data indicate that the capacity for ANF gene expression extends beyond atrial tissue, albeit at much reduced levels, and may suggest alternative, perhaps paraendocrine, functions for the peptide in these tissues.
How To Hide Valuables - Keeping Your Valuable Poss
How To Hide Valuables - Keeping Your Valuable Possessions Safe! by Kenny Heimbuch
Keeping Your Valuable Possessions Safe
The following are some of the prime hiding spaces for your valuables. Some of these ideas involve rather extensive and invasive work to implement, while others are quick fixes — it all depends on your needs, the level of threat to the security of your possessions, and the value you place on your property. Other factors to consider is how long do you need a hiding space for? Do you just need to hide something while you go on holidays? Or do you need a permanent solution?
In any case, keep the ultimate location of your hiding spots your personal secret!
Secret Stash: The Best Places To Hide Your Valuables
In The Yard
There are some bullet proof ways to hide things outside your home on your property so that your possessions are safe from others. One method is called cache tubes.
Using cache tubes involves getting some 6″ to 8″ PVC drain tubing several feet long, with two threaded end caps. Your stash can be placed in several plastic baggies, and then the end caps can be epoxied in place, or sealed with extreme pressure wheel bearing grease, both of which are also available at your local hardware store. This type of tubing, made out of PVC,is strong enough to withstand most natural elements, such as corrosives, salts and water. All one has to do, is to use a common pot hole digger to create a good hole to bury the tube.
Another way might be to hide things in hollowed out legs of patio furniture, or metal garden furniture legs, or even the hollow legs of a childs swingset. Again, put your valuables in several layers of plastic baggies.
In The Kitchen
The kitchen has some of the most accessible, natural hiding spots. Take for instance a large flour bin; your goods could be hidden in baggies and buried deep within. Or take an old packaging from frozen food and place your goods in there, and then re-glue the box. Hide that deep in the bottom of your chest freezer. Most people would not expect a box of frozen breaded liver to contain anything of worth.
In The Hallways
Consider burying small items in the bottom of potted plants, again, concealed in waterproof plastic containers, such as small aspirin bottles. If you have those sectional plastic shelves, you are in luck, as they have hollow parts as well which are perfect for hiding small items. Consider creating a few fake light switch boxes or fake electrical receptacles, they are also good spots.
In The Rooms
Do you have furniture that will allow for secret panels to be created in them? It might be possible to build some secret compartments in your sofa, end tables, chairs, or bookshelves. Forget about hiding anything under your bed though, in most break and enters where the home is ransacked, the burglars will turn the mattresses upside down looking for hidden items.
What about building a hidden empty spot behind one of the mirrors in the home? A mirror could conceal a hollow hiding spot quite nicely!
Again, if you seal a tiny item in a small, plastic waterproof container, you might be able to hide it in the gravel in your fish tank, or toilet bowl.
What about air conditioning ducts? If you have some ducts, you could put things in them that are not sensitive to temperatures.
What about building a hollow behind a portion of baseboard in your home? There is another option, since baseboards are so universal in every room of the house, they are natural hiding places.
Cutting away a small part of the drywall and making a hiding space which is later covered with wallpaper could be a good idea, provided that it is on a part of the wall where nobody is likely to touch the wall. Say higher up, near the ceiling might do the trick.
Making a book safe is a another old trick. Simply take a big, hardbound book and glue the pages together. Then use a drill to create some starter holes and then use a coping saw to cut out a rectangular section where some important things could be hidden. Glue this rectangular section to the back cover of the book.
If making candles interests you, you could even hide some things inside a homemade candle!
Pretty much any container or package can be uses to hide something. There are a number of 'decoy safes' or 'diversion safes' on the market that look like common everyday household items, such as fire extinguishers, smoke detectors, light switches, peanut butter jars, flower pots, lamps, etc.
How NOT To Hide Valuables!
By far the worst places to hide anything in your home are: closets, dresser drawers, night table, under mattresses, inside old clothes, or jewelry boxes. These are the first points of interest for any burglar.
Kenny Heimbuch is an author living in Ontario, Canada. Find more articles on home security and personal safety at http://livesafely.org
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Keeping Your Valuable Possessions Safe
The following are some of the prime hiding spaces for your valuables. Some of these ideas involve rather extensive and invasive work to implement, while others are quick fixes — it all depends on your needs, the level of threat to the security of your possessions, and the value you place on your property. Other factors to consider is how long do you need a hiding space for? Do you just need to hide something while you go on holidays? Or do you need a permanent solution?
In any case, keep the ultimate location of your hiding spots your personal secret!
Secret Stash: The Best Places To Hide Your Valuables
In The Yard
There are some bullet proof ways to hide things outside your home on your property so that your possessions are safe from others. One method is called cache tubes.
Using cache tubes involves getting some 6″ to 8″ PVC drain tubing several feet long, with two threaded end caps. Your stash can be placed in several plastic baggies, and then the end caps can be epoxied in place, or sealed with extreme pressure wheel bearing grease, both of which are also available at your local hardware store. This type of tubing, made out of PVC,is strong enough to withstand most natural elements, such as corrosives, salts and water. All one has to do, is to use a common pot hole digger to create a good hole to bury the tube.
Another way might be to hide things in hollowed out legs of patio furniture, or metal garden furniture legs, or even the hollow legs of a childs swingset. Again, put your valuables in several layers of plastic baggies.
In The Kitchen
The kitchen has some of the most accessible, natural hiding spots. Take for instance a large flour bin; your goods could be hidden in baggies and buried deep within. Or take an old packaging from frozen food and place your goods in there, and then re-glue the box. Hide that deep in the bottom of your chest freezer. Most people would not expect a box of frozen breaded liver to contain anything of worth.
In The Hallways
Consider burying small items in the bottom of potted plants, again, concealed in waterproof plastic containers, such as small aspirin bottles. If you have those sectional plastic shelves, you are in luck, as they have hollow parts as well which are perfect for hiding small items. Consider creating a few fake light switch boxes or fake electrical receptacles, they are also good spots.
In The Rooms
Do you have furniture that will allow for secret panels to be created in them? It might be possible to build some secret compartments in your sofa, end tables, chairs, or bookshelves. Forget about hiding anything under your bed though, in most break and enters where the home is ransacked, the burglars will turn the mattresses upside down looking for hidden items.
What about building a hidden empty spot behind one of the mirrors in the home? A mirror could conceal a hollow hiding spot quite nicely!
Again, if you seal a tiny item in a small, plastic waterproof container, you might be able to hide it in the gravel in your fish tank, or toilet bowl.
What about air conditioning ducts? If you have some ducts, you could put things in them that are not sensitive to temperatures.
What about building a hollow behind a portion of baseboard in your home? There is another option, since baseboards are so universal in every room of the house, they are natural hiding places.
Cutting away a small part of the drywall and making a hiding space which is later covered with wallpaper could be a good idea, provided that it is on a part of the wall where nobody is likely to touch the wall. Say higher up, near the ceiling might do the trick.
Making a book safe is a another old trick. Simply take a big, hardbound book and glue the pages together. Then use a drill to create some starter holes and then use a coping saw to cut out a rectangular section where some important things could be hidden. Glue this rectangular section to the back cover of the book.
If making candles interests you, you could even hide some things inside a homemade candle!
Pretty much any container or package can be uses to hide something. There are a number of 'decoy safes' or 'diversion safes' on the market that look like common everyday household items, such as fire extinguishers, smoke detectors, light switches, peanut butter jars, flower pots, lamps, etc.
How NOT To Hide Valuables!
By far the worst places to hide anything in your home are: closets, dresser drawers, night table, under mattresses, inside old clothes, or jewelry boxes. These are the first points of interest for any burglar.
Kenny Heimbuch is an author living in Ontario, Canada. Find more articles on home security and personal safety at http://livesafely.org
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