Regulatable atrial natriuretic peptide gene therapy for hypertension

Proceedings of the National Academy of Sciences, Vol. 102, No. 39. (27 September 2005), pp. 13789-13794.

Hypertension (HTN) is a disease that begins with dysfunctional renal-sodium excretion and progresses to a syndrome of highly elevated systolic, diastolic, and mean arterial pressures. Inadequacies in the therapy of HTN have led to the investigation of the gene therapy of this disease by using systemic overproduction of vasodilatory peptides, such as atrial natriuretic peptide (ANP). However, gene-therapy approaches to HTN using ANP are limited by the need for long-term ANP gene expression and, most important, control of ANP gene expression. Here, we introduce a helper-dependent adenoviral vector carrying the mifepristone (Mfp)-inducible gene-regulatory system to control in vivo ANP expression. In the BPH/2 mouse model of HTN, Mfp-inducible ANP expression was seen for a period of >120 days after administration of vector. Physiological effects of ANP, including decreased systolic blood pressure, increased urinary cGMP output, and decreases in heart weight as a percentage of body weight were also under the control of Mfp. Given these capabilities, this vector represents a paradigm for the gene therapy of HTN. 10.1073/pnas.0506807102

Quaix-en-Chartreuse

Resumen: Página nueva: {{Localidad de Francia | nomcommune= Quaix-en-Chartreuse | imagen_bandera = |imagen= |région=[[Ródano-Alpes]] |département=[[Isère]] |arrondissement=[[distrito de Grenoble]] |cant...

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{{Localidad de Francia
| nomcommune= Quaix-en-Chartreuse
| imagen_bandera =
|imagen=
|région=[[Ródano-Alpes]]
|département=[[Isère]]
|arrondissement=[[distrito de Grenoble]]
|canton=[[cantón de Saint-Égrève]]
|insee=38328
|cp=38950
|maire=
|mandat=[[2001]]-[[2008]]
|nomhab=Queylards (en [[idioma francés|francés]])
|intercomm=[[Communauté de communes du Balcon Sud de la Chartreuse]]
|longitude=
|latitude=
|alt moy=
|alt mini=
|alt maxi=
|hectares=
|km²=
|sans=740
|date-sans=1999

}}
''' Quaix-en-Chartreuse ''' es una población y [[comuna francesa]], en la región de [[Ródano-Alpes]], [[departamentos de Francia|departamento]] de [[Isère]], en el [[distrito de Grenoble]] y [[cantón de Saint-Égrève]].
==Demografía==
{{DemogFR|
1962 =
243 |
1968 = 306 |
1975 = 268 |
1982 = 415 |
1990 = 608 |
1999 = 740|
= |
sansdoublescomptes= 1962 }}
==Enlaces externos==
* [http://www.recensement.insee.fr/RP99/rp99/co_navigation.co_page?nivgeo=C&codgeo=38328&theme=ALL&typeprod=ALL&quelcas=LISTE INSEE]
[[Categoría:Localidades de Isère|Quaix en Chartreuse]]
{{miniesbozo|geografía de Francia}}[[fr:Quaix-en-Chartreuse]]

Food For Thought

A short while ago I listed three vegan podcasts.

Those three radio-like shows are popular and for good reason: they’re informative, interesting, funny, and reliable.

But there are plenty of other great podcasts, too. So here is another great vegan podcast:

Compassionate Cooks’ Food For Thought - http://compassionatecooks.com/podcast.htm

Don’t be fooled. This podcast is not just about cooking. Food For Thought is about all kinds of other vegan issues. Here’s a description of the podcast:

“‘Food for Thought’ offers a unique perspective that leaves listeners feeling supported, motivated, and inspired. Celebrating a way of life that encompasses compassion for everyone, this podcast addresses all aspects of eating a compassionate, healthful, whole foods, plant-based diet and advocates a sustainable food system that supports organic, local, seasonal fare. Each episode addresses commonly asked questions about being vegetarian/vegan, including those regarding animal rights, food, cooking, nutrition, and debunks the myths surrounding these issues. Drawing upon poetry, short stories, and other forms of literature, this is a unique podcast that works on many levels.”

Here’s a sample:




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Quincieu

Resumen: Página nueva: {{Localidad de Francia | nomcommune= Quincieu | imagen_bandera = |imagen= |région=[[Ródano-Alpes]] |département=[[Isère]] |arrondissement=[[distrito de Grenoble]] |canton=[[cantó...

---

{{Localidad de Francia
| nomcommune= Quincieu
| imagen_bandera =
|imagen=
|région=[[Ródano-Alpes]]
|département=[[Isère]]
|arrondissement=[[distrito de Grenoble]]
|canton=[[cantón de Tullins]]
|insee=38330
|cp=38470
|maire=
|mandat=[[2001]]-[[2008]]
|nomhab=
|intercomm=[[]]
|longitude=
|latitude=
|alt moy=
|alt mini=
|alt maxi=
|hectares=475
|km²=4.75
|sans=74
|date-sans=1999

}}
''' Quincieu ''' es una población y [[comuna francesa]], en la región de [[Ródano-Alpes]], [[departamentos de Francia|departamento]] de [[Isère]], en el [[distrito de Grenoble]] y [[cantón de Tullins]].
==Demografía==
{{DemogFR|
1962 =
100 |
1968 = 87 |
1975 = 69 |
1982 = 75 |
1990 = 73 |
1999 = 74|
= |
sansdoublescomptes= 1962 }}
==Enlaces externos==
* [http://www.recensement.insee.fr/RP99/rp99/co_navigation.co_page?nivgeo=C&codgeo=38330&theme=ALL&typeprod=ALL&quelcas=LISTE INSEE]
[[Categoría:Localidades de Isère]]
{{miniesbozo|geografía de Francia}}[[fr:Quincieu]]

Earthlings: Making The Connections

If you haven’t seen Earthlings, you should watch it.

You can buy it on DVD, find it at your library on DVD (if you’re lucky), or watch it online here.

It’s an excellent film about human animal interactions.

The film is difficult to watch if you’re sensitive to animal cruelty, so watch it when you’re feeling strong and have a box of tissues near you.

I watched the film in three parts on three separate days to help diffuse my strong emotional reaction to the movie. Conveniently, the film’s been broken up into three sections already, as posted here at Vegan Soapbox in 2007:

1. Earthlings part 1
2. Earthlings part 2
3. Earthlings part 3

The official website for Earthlings is http://www.isawearthlings.com/ where this synopsis is given:

“EARTHLINGS is a feature length documentary about humanity’s absolute dependence on animals (for pets, food, clothing, entertainment, and scientific research) but also illustrates our complete disrespect for these so-called ‘non-human providers.’ The film is narrated by Academy Award nominee Joaquin Phoenix (GLADIATOR) and features music by the critically acclaimed platinum artist Moby.”

“With an in-depth study into pet stores, puppy mills and animals shelters, as well as factory farms, the leather and fur trades, sports and entertainment industries, and finally the medical and scientific profession, EARTHLINGS uses hidden cameras and never before seen footage to chronicle the day-to-day practices of some of the largest industries in the world, all of which rely entirely on animals for profit. Powerful, informative and thought-provoking, EARTHLINGS is by far the most comprehensive documentary ever produced on the correlation between nature, animals, and human economic interests.”